Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50040855
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50000040(CHEMBL16192 | (+)(2-Benzhydryl-1-aza-bicyclo[2.2.2...)
Affinity DataKd:  5.37nMAssay Description:Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261(SR-14280 | SR-142801 | (S)-(+)-N-((3-[1-Benzoyl-3-...)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to wild type human NK3 receptor expressed in HEK293 cells assessed as [3H]IP accumulation after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataEC50:  0.710nMAssay Description:Agonist activity at wild type human NK3 receptor expressed in HEK293 cells assessed as [3H]IP accumulation after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261(SR-14280 | SR-142801 | (S)-(+)-N-((3-[1-Benzoyl-3-...)
Affinity DataKd:  18.6nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKd:  5.75nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401082(CHEMBL2203704)
Affinity DataKd:  16.2nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401080(CHEMBL2203706)
Affinity DataKd:  120nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401078(CHEMBL2203708)
Affinity DataKd:  123nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401077(CHEMBL2203709)
Affinity DataKd:  97.7nMAssay Description:Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401082(CHEMBL2203704)
Affinity DataKi:  0.300nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50000040(CHEMBL16192 | (+)(2-Benzhydryl-1-aza-bicyclo[2.2.2...)
Affinity DataKi:  0.400nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401078(CHEMBL2203708)
Affinity DataKi:  0.400nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261(SR-14280 | SR-142801 | (S)-(+)-N-((3-[1-Benzoyl-3-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401083(CHEMBL2203703)
Affinity DataKi:  0.700nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401083(CHEMBL2203703)
Affinity DataKi:  0.700nMAssay Description:Binding affinity at human NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401079(CHEMBL2203707)
Affinity DataKi:  0.700nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401079(CHEMBL2203707)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401080(CHEMBL2203706)
Affinity DataKi:  1.30nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401081(CHEMBL2203705)
Affinity DataKi:  1.40nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401077(CHEMBL2203709)
Affinity DataKi:  1.40nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401081(CHEMBL2203705)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401082(CHEMBL2203704)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401078(CHEMBL2203708)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401083(CHEMBL2203703)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401083(CHEMBL2203703)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to wild type human NK3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50220136(CHEMBL1471 | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluo...)
Affinity DataKi:  3nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401077(CHEMBL2203709)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50401080(CHEMBL2203706)
Affinity DataKi:  11.9nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261(SR-14280 | SR-142801 | (S)-(+)-N-((3-[1-Benzoyl-3-...)
Affinity DataKi:  210nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50220136(CHEMBL1471 | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluo...)
Affinity DataKi:  454nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity at human NK2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at human NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50000040(CHEMBL16192 | (+)(2-Benzhydryl-1-aza-bicyclo[2.2.2...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed