Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50040650
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50388626(CHEMBL2059435 | US9296736, 152 | US9593129, Exampl...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human MDM2 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataKd:  1nMAssay Description:Binding affinity to human MDM2 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50388626(CHEMBL2059435 | US9296736, 152 | US9593129, Exampl...)
Affinity DataIC50: 760nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity at p53 in human HCT116 cells expressing wild type p53 assessed as induction of p21 mRNA expression after 7 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397772(CHEMBL2177191 | US9296736, 185 | US9593129, Exampl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397774(CHEMBL2177189 | US9296736, 128)
Affinity DataIC50: 1.60E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397771(CHEMBL2059300 | US9593129, Example 67)
Affinity DataIC50: 1.90E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397775(CHEMBL2177188)
Affinity DataIC50: 3.10E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50: 4.30E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397773(CHEMBL2177190)
Affinity DataIC50: 5.50E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50: 7.10E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397777(CHEMBL2177186 | US9593129, Example 3)
Affinity DataIC50: 1.07E+4nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397778(CHEMBL2177813 | US9593129, Example 35)
Affinity DataIC50: 3.44E+4nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed