Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50039512
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM31285(BMCL163310 Compound 1 | CHEMBL361103 | benzodiazep...)
Affinity DataKd:  80nMAssay Description:Displacement of fluorescein-labeled p53 peptide from HDM2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM31286(benzodiazepinedione, 2)
Affinity DataKd:  4.80E+3nMAssay Description:Displacement of fluorescein-labeled p53 peptide from HDM2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEWS-Fli1 protein(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataKd:  9.48E+3nMAssay Description:Inhibition of interaction of EWS-Fli1 to GST-tagged RNA Helicase A (647-1075) by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTranscriptional regulator ERG(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataKd:  1.17E+4nMAssay Description:Binding affinity to ERG by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetETS translocation variant 1(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataKd:  1.74E+4nMAssay Description:Binding affinity to ETV1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPirin(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379276(CHEMBL1230119)
Affinity DataKd:  600nMAssay Description:Antagonist activity at pirin by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379277(CHEMBL90825)
Affinity DataKd:  1.60E+4nMAssay Description:Binding affinity to JNK1 allosteric site by AS-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379278(CHEMBL2011501)
Affinity DataKd:  700nMAssay Description:Orthosteric antagonist activity at M2 receptor by AS-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379281(CHEMBL2011504)
Affinity DataKd:  930nMAssay Description:Displacement of BakBH3 from Bcl-xL by DEL methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM36470(2-(4-(3,4-Dimethoxyphenylamino)-6-(quinolin-6-ylam...)
Affinity DataIC50: 270nMAssay Description:Competitive inhibition of Aurora A by DEL methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379280(CHEMBL2011503)
Affinity DataIC50: 680nMAssay Description:Inhibition of SRC by DEL methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379279(CHEMBL2011502)
Affinity DataKi:  4.50E+4nMAssay Description:Negative allosteric modulation at M2 receptor by AS-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed