Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50033764
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105748({4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidaz...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of p38alpha expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50296011(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50: 13nMAssay Description:Inhibition of SGK1 expressed in Escherichia coli or baculovirus-infected insect cells by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50350908(CHEMBL520308)
Affinity DataIC50: 15nMAssay Description:Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM31863(2,4-Bisanilinopyrimidine, 29)
Affinity DataIC50: 20nMAssay Description:Inhibition of AurA expressed in Escherichia coli or baculovirus-infected insect cells by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15997(2-({2-[(3-fluorophenyl)amino]pyrimidin-4-yl}amino)...)
Affinity DataIC50: 28nMAssay Description:Inhibition of JNK1 expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50138400(4-{4-[4-(Piperazine-1-sulfonyl)-phenyl]-pyrimidin-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278532(N-(2-amino-1-phenylethyl)-5-(1H-pyrrolo[2,3-b]pyri...)
Affinity DataIC50: 190nMAssay Description:Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50350909(CHEMBL1650061)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50350909(CHEMBL1650061)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of p38alpha expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of JNK1 expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM16223(compound 2 | 1H-pyrrolo[2,3-b]pyridine | 7-azaindo...)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25725(1,3-diphenylurea | Urea-based compound, 7)
Affinity DataIC50: 6.60E+5nMAssay Description:Inhibition of SYK expressed in Escherichia coli or baculovirus-infected insect cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)
Affinity DataKi:  19nMAssay Description:Inhibition of GSK3-beta expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed