Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50033589
TargetBeta-2 adrenergic receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347781(CHEMBL1802359)
Affinity DataKd:  100nMAssay Description:Binding affinity to human adrenergic beta2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50296957(4'-(2-((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan...)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at human adrenergic beta3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347782(CHEMBL1802360)
Affinity DataEC50:  400nMAssay Description:Agonist activity at human M1 muscarinic receptor expressed in CHO cells assessed as inhibition of carbachol-stimulated phosphatidyl-inositol hydrolys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347783(CHEMBL1223753)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human M1 muscarinic receptor expressed in CHO cells assessed as inhibition of carbachol-stimulated phosphatidyl-inositol hydrolys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347784(CHEMBL1802361)
Affinity DataEC50:  380nMAssay Description:Agonist activity at GPR109aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM23517(CHEMBL228244 | 2-[2-(4-methoxyphenoxy)acetamido]be...)
Affinity DataEC50:  1.25E+4nMAssay Description:Agonist activity at GPR109aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50184183(3,3'-difluoro-4'-{[5-(4-pyridin-4-yl-piperazine-1-...)
Affinity DataKi:  0.0450nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274013(1-(4-benzhydrylpiperazin-1-yl)-3-(3-methyl-1H-indo...)
Affinity DataKi:  0.300nMAssay Description:Displacement of radioligand from human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347779(CHEMBL1233771)
Affinity DataKi:  9nMAssay Description:Displacement of radioligand from human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50315603(2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,...)
Affinity DataKi:  18nMAssay Description:Displacement of radioligand from human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50306766(N2-(5-chloro-2-methoxyphenyl)-6-(3-methylbenzofura...)
Affinity DataKi:  32nMAssay Description:Displacement of radioligand from human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50318244((R)-N-(3-phenyl-1H-1,2,4-triazol-5-yl)-2-(m-tolylo...)
Affinity DataKi:  200nMAssay Description:Displacement of radioligand from human adenosine A2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50347780(CHEMBL1626224)
Affinity DataKi:  470nMAssay Description:Displacement of radioligand from human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50184194(3,3'-difluoro-4'-(pyridin-2-ylaminomethyl)-bipheny...)
Affinity DataKi:  815nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed