Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50033378
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataKd:  110nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataKd:  16nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataKd:  16nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataKd:  1.20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344123((R)-6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)p...)
Affinity DataKd:  1nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50341346((R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methyls...)
Affinity DataKd:  8.70nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344123((R)-6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)p...)
Affinity DataKd:  25nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344131(6-(2,4-difluorophenoxy)-N-isopropyl-1H-pyrazolo[3,...)
Affinity DataIC50: 23nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344129(6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)piper...)
Affinity DataIC50: 38nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344123((R)-6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)p...)
Affinity DataIC50: 45nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344134(N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 59nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344135(N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 84nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344137(N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 100nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344123((R)-6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)p...)
Affinity DataIC50: 109nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344130(6-(2,4-difluorophenoxy)-N-(tetrahydro-2H-pyran-4-y...)
Affinity DataIC50: 218nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344133(N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 257nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344136(N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 420nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344126(1-(4-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]py...)
Affinity DataIC50: 690nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344125([6-(2,4-Difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 795nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344138(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344128([6-(2,4-Difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344124((S)-6-(2,4-difluorophenoxy)-N-(1-(methylsulfonyl)p...)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344132(N-(6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50344127(6-(2,4-difluorophenoxy)-N-(2-(methylsulfonyl)ethyl...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed