Compile Data Set for Download or QSAR
Report error Found 102 Enz. Inhib. hit(s) with all data for entry = 50033306
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(N-hydroxy-1-(2-methoxyethyl)-4-(4-(4-(trifluoromet...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(N-hydroxy-1-(2-methoxyethyl)-4-(4-(4-(trifluoromet...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(N-hydroxy-1-(2-methoxyethyl)-4-(4-(4-(trifluoromet...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(N-hydroxy-1-(2-methoxyethyl)-4-(4-(4-(trifluoromet...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(N-hydroxy-1-(2-methoxyethyl)-4-(4-(4-(trifluoromet...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343079(N-hydroxy-4-(4-(3-(5-(4-methoxyphenyl)-2H-tetrazol...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343078(N-hydroxy-4-(4-(4-(4-methoxybenzoyl)piperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343083(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-1H-tet...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(N-hydroxy-4-(4-(3-(1-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343052(N-hydroxy-4-(4-(3-(4-methoxybenzamido)propoxy)phen...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343086(N-hydroxy-4-(4-(3-(4-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343085(1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)...)
Affinity DataKi:  2nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343083(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-1H-tet...)
Affinity DataKi:  3nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343087(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(N-hydroxy-4-(4-(3-(1-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(N-hydroxy-1-(2-methoxyethyl)-4-(4-(4-(trifluoromet...)
Affinity DataKi:  14nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  28nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  31nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343085(1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)...)
Affinity DataKi:  37nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  44nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343086(N-hydroxy-4-(4-(3-(4-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  59nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343088(N-hydroxy-4-(4-(3-(1-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  72nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343086(N-hydroxy-4-(4-(3-(4-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  74nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  80nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  110nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343087(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  130nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343087(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  140nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  160nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343080(N-hydroxy-4-(4-(3-(5-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  170nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343084(N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataKi:  180nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343081(N-hydroxy-1-(2-methoxyethyl)-4-(4-(3-(5-(4-(triflu...)
Affinity DataKi:  230nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343082(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-2H-tet...)
Affinity DataKi:  240nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343083(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-1H-tet...)
Affinity DataKi:  250nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343085(1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)...)
Affinity DataKi:  260nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343085(1-ethyl-N-hydroxy-4-(4-(3-(3-(4-(trifluoromethoxy)...)
Affinity DataKi:  370nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343083(N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-1H-tet...)
Affinity DataKi:  400nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
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