Compile Data Set for Download or QSAR
Report error Found 135 Enz. Inhib. hit(s) with all data for entry = 50033148
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340380(N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340399(4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)b...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340389(3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340394(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340394(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340389(3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340392(4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)eth...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340373(4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340402(3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340396(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340376(3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2....)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340402(3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174281(4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340395(3-(4-(4-methoxybutyl)bicyclo[2.2.2]octan-1-yl)-4-m...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340398(3-(4-(ethoxymethyl)bicyclo[2.2.2]octan-1-yl)-4-met...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340399(4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)b...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340395(3-(4-(4-methoxybutyl)bicyclo[2.2.2]octan-1-yl)-4-m...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340377(4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(tr...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340401(3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340403(3-chloro-4-(5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340384(N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174281(4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340403(3-chloro-4-(5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340401(3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340400(3-(4-(2-(ethylthio)ethyl)bicyclo[2.2.2]octan-1-yl)...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340372(3-(4-(2-(isopropylsulfonyl)ethyl)bicyclo[2.2.2]oct...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340392(4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)eth...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340400(3-(4-(2-(ethylthio)ethyl)bicyclo[2.2.2]octan-1-yl)...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340387(N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340398(3-(4-(ethoxymethyl)bicyclo[2.2.2]octan-1-yl)-4-met...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340372(3-(4-(2-(isopropylsulfonyl)ethyl)bicyclo[2.2.2]oct...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340382(4-methyl-3-(4-(2-(methylsulfonyl)ethyl)bicyclo[2.2...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340373(4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340374(4-methyl-3-(4-(2-(propylsulfonyl)ethyl)bicyclo[2.2...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340375(3-(4-(2-(tert-butylsulfonyl)ethyl)bicyclo[2.2.2]oc...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340376(3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2....)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340377(4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(tr...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340375(3-(4-(2-(tert-butylsulfonyl)ethyl)bicyclo[2.2.2]oc...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340374(4-methyl-3-(4-(2-(propylsulfonyl)ethyl)bicyclo[2.2...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340378(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340379(3-(2-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bi...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340380(N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340378(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340371(3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340381(3-(2-bromophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bic...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340379(3-(2-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bi...)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
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