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Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50022641
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50653054(Tp-010 | BTZO-1)
Affinity DataIC50: 71nMAssay Description:Inhibition of [3H]-BTZO-1 binding to recombinant human C-terminal His-tagged MIF expressed in Escherichia coli BL21 (DE3) measured after 3 hrs by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50653054(Tp-010 | BTZO-1)
Affinity DataKd:  88nMAssay Description:Binding affinity to BTZO-12 sensor chip immobilized human MIF expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50653054(Tp-010 | BTZO-1)
Affinity DataKd:  157nMAssay Description:Binding affinity to recombinant human C-terminal His-tagged MIF expressed in Escherichia coli BL21 (DE3) at 400 nM incubated for 6 hrs using labelled...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50065387(CHEBI:78886 | E319)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of [3H]-BTZO-1 binding to recombinant human C-terminal His-tagged MIF expressed in Escherichia coli BL21 (DE3) measured after 3 hrs by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50270612(15-deoxy-d12,14-prostaglandin J2 | 15-deoxy-delta1...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of [3H]-BTZO-1 binding to recombinant human C-terminal His-tagged MIF expressed in Escherichia coli BL21 (DE3) measured after 3 hrs by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Rattus norvegicus)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50270612(15-deoxy-d12,14-prostaglandin J2 | 15-deoxy-delta1...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant rat MIF expressed in Escherichia coli BL21 (DE3) assessed as reduction in tautomerase activity using L-dopachrome carboxy-m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Rattus norvegicus)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50653055(L-sulforaphane)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of recombinant rat MIF expressed in Escherichia coli BL21 (DE3) assessed as reduction in tautomerase activity using L-dopachrome carboxy-m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50653055(L-sulforaphane)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of [3H]-BTZO-1 binding to recombinant human C-terminal His-tagged MIF expressed in Escherichia coli BL21 (DE3) measured after 3 hrs by SPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Rattus norvegicus)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50065387(CHEBI:78886 | E319)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant rat MIF expressed in Escherichia coli BL21 (DE3) assessed as reduction in tautomerase activity using L-dopachrome carboxy-m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Rattus norvegicus)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50653054(Tp-010 | BTZO-1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant rat MIF expressed in Escherichia coli BL21 (DE3) assessed as reduction in tautomerase activity using L-dopachrome carboxy-m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage migration inhibitory factor(Rattus norvegicus)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50186426(CHEMBL210858 | US8618147, ISO-1 | methyl 2-(3-(4-h...)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of recombinant rat MIF expressed in Escherichia coli BL21 (DE3) assessed as reduction in tautomerase activity using L-dopachrome carboxy-m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMacrophage migration inhibitory factor(Human)
Takeda Pharmaceutical Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50186426(CHEMBL210858 | US8618147, ISO-1 | methyl 2-(3-(4-h...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]-BTZO-1 binding to recombinant human C-terminal His-tagged MIF expressed in Escherichia coli BL21 (DE3) measured after 3 hrs by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)