Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50032778
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity at human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334486(trans-4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluo...)
Affinity DataIC50: 3.20nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144009(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Affinity DataIC50: 21nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334495((R)-3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorom...)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334480(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluoromethoxy)...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334480(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluoromethoxy)...)
Affinity DataIC50: 36nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334482(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluoromethoxy)...)
Affinity DataIC50: 39nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334478(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol...)
Affinity DataIC50: 43nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334486(trans-4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluo...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334486(trans-4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluo...)
Affinity DataIC50: 46nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334478(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334476(trans-4-((5-(4-tert-butylcyclohexyl)-3-(4-(trifluo...)
Affinity DataIC50: 63nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 84nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334479(3-(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluorometho...)
Affinity DataIC50: 95nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334483(N-((2H-tetrazol-5-yl)methyl)-4-((3-(3,5-dichloroph...)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334490(4-((5-cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334484(4-(1-(3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyraz...)
Affinity DataIC50: 130nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144009(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334490(4-((5-cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50: 160nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334476(trans-4-((5-(4-tert-butylcyclohexyl)-3-(4-(trifluo...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334507(4-((5-(4-(methylsulfonyl)phenyl)-3-(4-(trifluorome...)
Affinity DataIC50: 220nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334479(3-(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluorometho...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334501(3-(4-(1-(3,5-bis(4-(trifluoromethoxy)phenyl)-1H-py...)
Affinity DataIC50: 250nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334482(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluoromethoxy)...)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334512(3-(3-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyra...)
Affinity DataIC50: 330nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334477(3-(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyra...)
Affinity DataIC50: 370nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetUncharacterized protein [173-650](Dog)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at dog GCGR assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334509(4-((3-(1-(4-chlorophenyl)ethyl)-5-(4-(trifluoromet...)
Affinity DataIC50: 430nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334500(trans-3-(4-((5-(4-tert-butylcyclohexyl)-3-(4-(trif...)
Affinity DataIC50: 480nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334477(3-(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyra...)
Affinity DataIC50: 490nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334511(4-((5-(4-(1-(4-chlorophenyl)ethyl)phenyl)-3-(4-(tr...)
Affinity DataIC50: 520nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334485(2-(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyra...)
Affinity DataIC50: 560nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334505(4-((3-(4-(methylsulfonyl)phenyl)-5-(4-(trifluorome...)
Affinity DataIC50: 570nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334483(N-((2H-tetrazol-5-yl)methyl)-4-((3-(3,5-dichloroph...)
Affinity DataIC50: 650nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334510(3-(4-((5-(4-(1-(4-chlorophenyl)ethyl)phenyl)-3-(4-...)
Affinity DataIC50: 730nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334489(4-((3-cyclohexyl-5-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50: 810nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334489(4-((3-cyclohexyl-5-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50: 910nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334502(4-(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyra...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334515(4-(3-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyra...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334513(3-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334491(3-(4-((3-cyclohexyl-1-(4-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334506(3-(4-((5-(4-(methylsulfonyl)phenyl)-3-(4-(trifluor...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144009(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334484(4-(1-(3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyraz...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334498(3-(4-((1-cyclohexyl-5-(4-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at mouse GCGR assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334487(4-((3-cyclohexyl-5-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334490(4-((5-cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334508(3-(4-((3-(1-(4-chlorophenyl)ethyl)-5-(4-(trifluoro...)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
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