Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50032648
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332656(ethyl 3-carbamoyl-1-(2'-(trifluoromethoxy)biphenyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332657(N5-ethyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332649(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332652(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332650(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332647(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50: 106nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332662(1-(4'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50: 106nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332654(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50: 115nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332655(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50: 132nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332651(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50: 147nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332649(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50: 149nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332659(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)
Affinity DataIC50: 155nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332653(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50: 185nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332658(1-(2',3'-dichlorobiphenyl-3-yl)-1H-pyrazole-3,5-di...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332650(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50: 203nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325771(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50: 224nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332646(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50: 282nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332651(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50: 299nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332648(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)
Affinity DataIC50: 325nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332661(1-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50: 477nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332655(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50: 554nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332660(1-(2',6'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 715nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332647(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50: 802nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 810nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332659(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)
Affinity DataIC50: 915nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of Nav1.5 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 2.50E+4nMAssay Description:Induction of PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332646(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50: 1.51E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332648(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)
Affinity DataIC50: 1.18E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332645(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-1H-pyr...)
Affinity DataIC50: 2.00E+6nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  230nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataKi:  340nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed