Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50039321
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  620nMAssay Description:Binding affinity to TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  5nMAssay Description:Binding affinity to JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  32nMAssay Description:Binding affinity to TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  180nMAssay Description:Binding affinity to JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  220nMAssay Description:Binding affinity to JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  21nMAssay Description:Binding affinity to JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(methyl 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(methyl 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4...)
Affinity DataIC50: 760nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 850nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332297(ethyl 3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-...)
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332297(ethyl 3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-...)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332305(ethyl 3-(5-amino-1-(2-fluorobenzoyl)-1H-1,2,4-tria...)
Affinity DataIC50: 6.04E+3nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332309(ethyl 3-(5-amino-1-(4-(trifluoromethyl)benzoyl)-1H...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332305(ethyl 3-(5-amino-1-(2-fluorobenzoyl)-1H-1,2,4-tria...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332297(ethyl 3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(methyl 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
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