Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50032646
TargetMetabotropic glutamate receptor 3(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(N-(4-Chlorophenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataEC50:  1.34E+4nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataEC50:  8.90E+3nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(N-(4-Methoxyphenyl)-7-oxo-7,7a-dihydrocyclopropa[b...)
Affinity DataEC50:  1.04E+4nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(N-(4-Chlorophenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataIC50: 800nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(N-(4-Methoxyphenyl)-7-oxo-7,7a-dihydrocyclopropa[b...)
Affinity DataIC50: 1.00E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataIC50: 1.50E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(N-(4-Methylphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataKi:  600nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(N-(4-Methoxyphenyl)-7-oxo-7,7a-dihydrocyclopropa[b...)
Affinity DataKi:  800nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(N-(4-Chlorophenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332631(N-(4-Fluorophenyl)-7-oxo-7,7a-dihydrocyclopropa[b]...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed