Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50033487
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50174677((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Affinity DataEC50:  24nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM33493(2-(3-benzyl-2-iminobenzimidazol-1-yl)ethanol;hydro...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346272(1-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346271(1-(3-allyl-2-imino-2,3-dihydro-1H-benzo[d]imidazol...)
Affinity DataEC50:  4.04E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346270(2-(2-amino-5-phenylthiophene-3-carbonyl)-N-(4-meth...)
Affinity DataEC50:  8.98E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346269(2-methyl-7-((6-methylpyridin-2-ylamino)(3,4,5-trim...)
Affinity DataEC50:  5.92E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346268(1-(3-benzyl-2-imino-2,3-dihydro-1H-benzo[d]imidazo...)
Affinity DataEC50:  3.85E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346267((2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4,6-di...)
Affinity DataEC50:  2.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346266((2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-cyclopropylbenzy...)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346265((2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluo...)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50174679((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Affinity DataEC50:  67nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM30717(1-[2-azanylidene-3-(phenylmethyl)benzimidazol-1-yl...)
Affinity DataEC50:  4.60E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50313364((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Affinity DataEC50:  12nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346264((2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-methylphe...)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50244463((2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-[2-(4-methyl-be...)
Affinity DataEC50:  8nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346263(2-(3-(4-chlorobenzyl)-2-imino-2,3-dihydro-1H-benzo...)
Affinity DataEC50:  3.11E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346262(2-(3-(4-chlorobenzyl)-2-imino-2,3-dihydro-1H-benzo...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM79640(1-(2-furanyl)-2-[2-imino-3-(phenylmethyl)-1-benzim...)
Affinity DataEC50:  3.47E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346260(2-(3-benzyl-2-imino-2,3-dihydro-1H-benzo[d]imidazo...)
Affinity DataEC50:  1.91E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM42468(cid_6602706 | CHEMBL1624727 | 2-[3-[(4-chloropheny...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50346258(2-(3-benzyl-2-imino-2,3-dihydro-1H-benzo[d]imidazo...)
Affinity DataEC50:  1.62E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed