Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50040332
TargetHistamine H4 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataEC50:  12.6nMAssay Description:Agonist activity at human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H4 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataEC50:  15.8nMAssay Description:Agonist activity at human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKd:  0.0870nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50346209(5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataIC50: 0.631nMAssay Description:Inverse agonist activity at human histamine H3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392759(CHEMBL2151157)
Affinity DataIC50: 2.51nMAssay Description:Inverse agonist activity at human histamine H3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50247054(GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...)
Affinity DataKi:  0.126nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50392760(CHEMBL2151158)
Affinity DataKi:  0.170nMAssay Description:Antagonist activity at human muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50074629(CHEMBL278462 | 4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-yn...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50346209(5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50200647((R)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)naphtha...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50224192((R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50341447(4-[(4-Chlorophenyl)methyl]-2-({(2R)-1-[4-(4-{[3-(h...)
Affinity DataKi:  0.251nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392759(CHEMBL2151157)
Affinity DataKi:  0.316nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392761(CHEMBL2151155)
Affinity DataKi:  0.316nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50370569(A-349821 | A-349,821)
Affinity DataKi:  0.398nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392763(CHEMBL2151195)
Affinity DataKi:  0.501nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50247054(GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...)
Affinity DataKi:  0.631nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50158601(CHEMBL361355 | A-317920 | Furan-2-carboxylic acid ...)
Affinity DataKi:  0.631nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392765(CHEMBL2151196)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50224192((R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-...)
Affinity DataKi:  0.930nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50146835(1-(4-Chloro-phenyl)-4-(4-cyclopentyl-piperazin-1-y...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Affinity DataKi:  1.35nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50370569(A-349821 | A-349,821)
Affinity DataKi:  1.58nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392764(CHEMBL2151194)
Affinity DataKi:  1.58nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50119707(4-[3-(4-Hexanoyl-phenoxy)-propyl]-piperazine-1-car...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50120543(7-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50200647((R)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)naphtha...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  2.51nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50392763(CHEMBL2151195)
Affinity DataKi:  3.16nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  3.98nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine receptor H3(Rhesus macaque)
TBA

Curated by ChEMBL
LigandPNGBDBM50193199((S,E)-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to rhesus monkey histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50193199((S,E)-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50128875([3-(4-Chloro-phenyl)-3-pyridin-2-yl-propyl]-[4-(1H...)
Affinity DataKi:  7nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  9.24nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392762(CHEMBL2151156)
Affinity DataKi:  12.6nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50128875([3-(4-Chloro-phenyl)-3-pyridin-2-yl-propyl]-[4-(1H...)
Affinity DataKi:  15nMAssay Description:Binding affinity to guinea pig histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50341447(4-[(4-Chlorophenyl)methyl]-2-({(2R)-1-[4-(4-{[3-(h...)
Affinity DataKi:  15.8nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50392760(CHEMBL2151158)
Affinity DataKi:  18nMAssay Description:Binding affinity to guinea pig histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  50.1nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  50.1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392762(CHEMBL2151156)
Affinity DataKi:  50.1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50158601(CHEMBL361355 | A-317920 | Furan-2-carboxylic acid ...)
Affinity DataKi:  100nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  126nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  794nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392761(CHEMBL2151155)
Affinity DataKi:  2.51E+3nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed