Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50039319
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331872(5-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331871(5-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331870(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 80nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331869(6-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331868(6-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331867(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331866(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331865(4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidi...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluoro...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331865(4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidi...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331867(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331866(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18525(N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluoro...)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331868(6-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331869(6-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331872(5-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331870(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50331871(5-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed