Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50032605
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331808((R)-9-fluoro-6-(1,1,1-trifluoro-3-methylbutan-2-yl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331824(6-(2-chloro-4,6-difluorophenylamino)-9-fluorobenzo...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331825(6-(2,6-dichlorophenylamino)-9-fluorobenzo[c][1,6]n...)
Affinity DataIC50: 14nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331817(6-(3,3-dimethylbutan-2-ylamino)-9-fluorobenzo[c][1...)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331829((S)-9-fluoro-6-(3-methylbutan-2-ylamino)benzo[c][1...)
Affinity DataIC50: 27nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK2 expressed in human Du-145 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331808((R)-9-fluoro-6-(1,1,1-trifluoro-3-methylbutan-2-yl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of JAK2 expressed in human Du-145 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331821(6-(2,6-dichlorobenzylamino)-9-fluorobenzo[c][1,6]n...)
Affinity DataIC50: 53nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331831((S)-9-fluoro-6-(1,1,1-trifluoro-3-methylbutan-2-yl...)
Affinity DataIC50: 55nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331827(6-(cyclobutylamino)-9-fluorobenzo[c][1,6]naphthyri...)
Affinity DataIC50: 75nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331828(9-fluoro-6-(isopropylamino)benzo[c][1,6]naphthyrid...)
Affinity DataIC50: 139nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331826(9-fluoro-6-((7R)-1,6,6-trimethylbicyclo[3.1.1]hept...)
Affinity DataIC50: 200nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331832(9-fluoro-6-(3-hydroxy-2,2-dimethylpropylamino)benz...)
Affinity DataIC50: 274nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331819(6-[(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-ylm...)
Affinity DataIC50: 512nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331822(6-(cyclopropyl(1-methylpiperidin-4-yl)amino)-9-flu...)
Affinity DataIC50: 540nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331814(2-(3,3-dimethylbutan-2-ylamino)-3-(pyridin-2-yl)-1...)
Affinity DataIC50: 630nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331830(6-(3,3-difluorocyclobutylamino)-9-fluorobenzo[c][1...)
Affinity DataIC50: 750nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331820(9-fluoro-6-(pyridin-2-ylmethylamino)benzo[c][1,6]n...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331810(3-phenyl-2-(pyridin-4-ylmethylamino)-1,6-naphthyri...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331818(6-(3-amino-2,2-dimethylpropylamino)-9-fluorobenzo[...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandPNGBDBM50331808((R)-9-fluoro-6-(1,1,1-trifluoro-3-methylbutan-2-yl...)
Affinity DataIC50: 3.50E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331813(2-(1-(2,4-dichloro-5-fluorophenyl)ethylamino)-3-(4...)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331823(9-fluoro-6-(3-fluorophenylamino)benzo[c][1,6]napht...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331816(N-(2-(dimethylamino)ethyl)-2-(3,3-dimethylbutan-2-...)
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331815(2-(3,3-dimethylbutan-2-ylamino)-3-(3-phenyl-1,2,4-...)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331812(2-(3,3-difluoropyrrolidin-1-yl)-3-(4-fluorophenyl)...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50331811(3-(4-fluorophenyl)-2-(neopentylamino)-1,6-naphthyr...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed