Compile Data Set for Download or QSAR
Report error Found 88 Enz. Inhib. hit(s) with all data for entry = 50032534
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330750(CHEMBL1277126)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330750(CHEMBL1277126)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330750(CHEMBL1277126)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330750(CHEMBL1277126)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330750(CHEMBL1277126)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 3.98E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 3.98E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330753(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 3.98E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330749(1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepi...)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataIC50: 6.31E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417375(CHEMBL1278115)
Affinity DataIC50: 6.31E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417355(CHEMBL1278114)
Affinity DataIC50: 6.31E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002087(4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thi...)
Affinity DataKi:  0.158nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417376(CHEMBL1278116)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataKi:  4.68nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.62nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  6.31nMAssay Description:Antagonist activity against human histamine H1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50330748(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  8.71nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
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