Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50032149
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199769((S)-3-((4S,7S)-7-(isoquinoline-1-carboxamido)-6,10...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324947((R)-2-((S)-4-(2-(2-(dimethylamino)quinolin-4-yl)et...)
Affinity DataIC50: 3.61nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324946((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(quinolin-4-yl)e...)
Affinity DataIC50: 4.77nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324937((R)-2-((S)-2-isopropyl-4-(2-(naphthalen-1-yl)ethyl...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324948((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(quinolin-5-yl)e...)
Affinity DataIC50: 5.81nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324960((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(2,5,6-trimethyl...)
Affinity DataIC50: 9.18nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324938((R)-2-((S)-4-(2-(3-chlorophenylamino)ethylamino)-2...)
Affinity DataIC50: 11.2nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324950((R)-2-((S)-2-isopropyl-4-(2-(isoquinolin-4-yl)ethy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324957((R)-2-((S)-4-(2-(5,6-dimethyl-1H-benzo[d]imidazol-...)
Affinity DataIC50: 14.5nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324956((R)-2-((S)-2-isopropyl-4-(2-(5-methyl-1H-benzo[d]i...)
Affinity DataIC50: 15.3nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324952((R)-2-((S)-2-isopropyl-4-(2-(2-methyl-1H-indol-3-y...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324936((R)-2-((S)-4-(2-(1H-indol-3-yl)ethylamino)-2-isopr...)
Affinity DataIC50: 23.1nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324958((S)-3-((S)-2-isopropyl-4-(2-(2-methyl-1H-benzo[d]i...)
Affinity DataIC50: 23.8nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324959((S)-3-((S)-2-isopropyl-4-oxo-4-(2-(2-(pyridin-3-yl...)
Affinity DataIC50: 26.5nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324955((R)-2-((S)-4-(2-(1H-benzo[d]imidazol-1-yl)ethylami...)
Affinity DataIC50: 33.7nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324935((R)-2-((S)-4-(2-(5-fluoro-1H-indol-3-yl)ethylamino...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324953((R)-2-((S)-4-(2-(1,2-dimethyl-1H-indol-3-yl)ethyla...)
Affinity DataIC50: 42.5nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324954((R)-2-((S)-4-(2-(1H-indol-1-yl)ethylamino)-2-isopr...)
Affinity DataIC50: 45.3nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324949((R)-2-((S)-4-(2-(2-(2-(dimethylamino)ethoxy)quinol...)
Affinity DataIC50: 102nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324940((R)-2-((S)-4-((2-carboxyethyl)(2-phenoxyethyl)amin...)
Affinity DataIC50: 114nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324939((2R)-2-((2S)-2-isopropyl-4-oxo-4-(3-phenoxypiperid...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324943((S)-3-((S)-2-isopropyl-4-oxo-4-(3-oxo-3-phenylprop...)
Affinity DataIC50: 398nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324944((R)-2-((S)-2-isopropyl-4-(3-(4-methoxyphenyl)propy...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324945((R)-2-((S)-2-isopropyl-4-oxo-4-(3-phenylpropylamin...)
Affinity DataIC50: 444nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324942((R)-2-((S)-2-isopropyl-4-oxo-4-(2-phenoxyethylamin...)
Affinity DataIC50: 539nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324941((R)-2-((S)-2-isopropyl-4-(isopropyl(2-phenoxyethyl...)
Affinity DataIC50: 584nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324951((R)-2-((S)-2-isopropyl-4-oxo-4-(4-phenylpiperazin-...)
Affinity DataIC50: 7.81E+3nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324937((R)-2-((S)-2-isopropyl-4-(2-(naphthalen-1-yl)ethyl...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199769((S)-3-((4S,7S)-7-(isoquinoline-1-carboxamido)-6,10...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324953((R)-2-((S)-4-(2-(1,2-dimethyl-1H-indol-3-yl)ethyla...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324938((R)-2-((S)-4-(2-(3-chlorophenylamino)ethylamino)-2...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324960((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(2,5,6-trimethyl...)
Affinity DataKi:  1.26nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324952((R)-2-((S)-2-isopropyl-4-(2-(2-methyl-1H-indol-3-y...)
Affinity DataKi:  1.29nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324946((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(quinolin-4-yl)e...)
Affinity DataKi:  1.31nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324948((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(quinolin-5-yl)e...)
Affinity DataKi:  1.81nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324957((R)-2-((S)-4-(2-(5,6-dimethyl-1H-benzo[d]imidazol-...)
Affinity DataKi:  2.81nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324947((R)-2-((S)-4-(2-(2-(dimethylamino)quinolin-4-yl)et...)
Affinity DataKi:  3nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324959((S)-3-((S)-2-isopropyl-4-oxo-4-(2-(2-(pyridin-3-yl...)
Affinity DataKi:  3.85nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324954((R)-2-((S)-4-(2-(1H-indol-1-yl)ethylamino)-2-isopr...)
Affinity DataKi:  4.03nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324950((R)-2-((S)-2-isopropyl-4-(2-(isoquinolin-4-yl)ethy...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324958((S)-3-((S)-2-isopropyl-4-(2-(2-methyl-1H-benzo[d]i...)
Affinity DataKi:  4.68nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324956((R)-2-((S)-2-isopropyl-4-(2-(5-methyl-1H-benzo[d]i...)
Affinity DataKi:  4.85nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324936((R)-2-((S)-4-(2-(1H-indol-3-yl)ethylamino)-2-isopr...)
Affinity DataKi:  5.02nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199769((S)-3-((4S,7S)-7-(isoquinoline-1-carboxamido)-6,10...)
Affinity DataKi:  7nMAssay Description:Inhibition of mouse ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324935((R)-2-((S)-4-(2-(5-fluoro-1H-indol-3-yl)ethylamino...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataKi:  9nMAssay Description:Inhibition of mouse ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324940((R)-2-((S)-4-((2-carboxyethyl)(2-phenoxyethyl)amin...)
Affinity DataKi:  9.24nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCaspase-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50324952((R)-2-((S)-2-isopropyl-4-(2-(2-methyl-1H-indol-3-y...)
Affinity DataKi:  13.4nMAssay Description:Inhibition of mouse ICEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
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