Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50032007
TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50: 0.00200nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323132((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323133((R)-2-(4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phth...)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320359((S)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320334((R)-(4-(4-(4-(dimethylamino)phenyl)phthalazin-1-yl...)
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323138((R)-(4-(4-(indolin-1-yl)phthalazin-1-yl)-3-methylp...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323137((R)-(4-(4-(1H-pyrrol-1-yl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323128((S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323145((R)-(3-methyl-4-(4-phenylpyrido[4,3-d]pyridazin-1-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323144((R)-(3-methyl-4-(5-phenylpyrido[2,3-d]pyridazin-8-...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320357((4-(4-(3,4-dichlorophenyl)phthalazin-1-yl)piperazi...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320362(phenyl(4-(4-phenylphthalazin-1-yl)piperazin-1-yl)m...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323129((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323130((R)-(3-methyl-4-(4-(4-morpholinophenyl)phthalazin-...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323134((R)-(3-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)p...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323136((R)-(3-methyl-4-(4-(pyridin-2-yl)phthalazin-1-yl)p...)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323143((R)-(3-methyl-4-(8-phenylpyrido[3,2-d]pyridazin-5-...)
Affinity DataIC50: 66nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323135((R)-(3-methyl-4-(4-(pyridin-3-yl)phthalazin-1-yl)p...)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323139((R)-(4-(4-(furan-2-yl)phthalazin-1-yl)-3-methylpip...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323140((R)-(4-(4-(1H-imidazol-1-yl)phthalazin-1-yl)-3-met...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323141((R)-(3-methyl-4-(4-(pyridazin-1(2H)-yl)phthalazin-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323142((R)-(4-(4-(pyrimidin-5-yl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323131((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed