Compile Data Set for Download or QSAR
Report error Found 150 Enz. Inhib. hit(s) with all data for entry = 50039246
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322882BDBM50322882(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322883BDBM50322883(3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322916BDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322884BDBM50322884(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322886BDBM50322886(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322891BDBM50322891(3-(N-(3-cyanophenyl)methylsulfonamido)-N-((2S,3R)-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322888BDBM50322888(3-(N-(4-chlorophenyl)methylsulfonamido)-N-((2S,3R)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322890BDBM50322890(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322914BDBM50322914(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322885BDBM50322885(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50231682BDBM50231682(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322915BDBM50322915(3-(ethylsulfonyl)-N-((2S,3R)-3-hydroxy-1-phenyl-4-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322877BDBM50322877(N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2...)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322907BDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322892BDBM50322892(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322889BDBM50322889(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322882BDBM50322882(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322906BDBM50322906(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 21nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322895BDBM50322895(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322910BDBM50322910(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 26nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322886BDBM50322886(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 29nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322879BDBM50322879(N-((2S,3R)-3-hydroxy-4-(6-methylheptan-2-ylamino)-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322886BDBM50322886(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 35nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322883BDBM50322883(3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifl...)
Affinity DataIC50: 41nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322916BDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)
Affinity DataIC50: 42nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322883BDBM50322883(3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322882BDBM50322882(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 53nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322885BDBM50322885(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 68nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322910BDBM50322910(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322894BDBM50322894(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 126nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322884BDBM50322884(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 126nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322886BDBM50322886(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 145nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322883BDBM50322883(3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifl...)
Affinity DataIC50: 160nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322882BDBM50322882(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322914BDBM50322914(N-((2S,3R)-4-((S)-1-(cyclohexylamino)-1-oxopropan-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322884BDBM50322884(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 180nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322902BDBM50322902(3-(N-benzylmethylsulfonamido)-N-((2S,3R)-4-((S)-1-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322887BDBM50322887(3-(N-(4-cyanophenyl)methylsulfonamido)-N-((2S,3R)-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322880BDBM50322880(N-((2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 193nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322916BDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)
Affinity DataIC50: 205nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322879BDBM50322879(N-((2S,3R)-3-hydroxy-4-(6-methylheptan-2-ylamino)-...)
Affinity DataIC50: 207nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322907BDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 210nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322915BDBM50322915(3-(ethylsulfonyl)-N-((2S,3R)-3-hydroxy-1-phenyl-4-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322915BDBM50322915(3-(ethylsulfonyl)-N-((2S,3R)-3-hydroxy-1-phenyl-4-...)
Affinity DataIC50: 220nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322880BDBM50322880(N-((2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 243nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322885BDBM50322885(N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifluoromethy...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322916BDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)
Affinity DataIC50: 275nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322907BDBM50322907(CHEMBL1210353 | CHEMBL1210357 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 280nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322905BDBM50322905(CHEMBL1788375 | CHEMBL1210351 | N-((2S,3R)-3-hydro...)
Affinity DataIC50: 290nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322916BDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
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