Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50031869
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320821(N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(4-flu...)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320810(N-(4-(3-(3-aminopropanamido)phenyl)-3-cyano-6-(4-f...)
Affinity DataIC50: 7.40nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320822(N-[4-{3-[(2-Aminoethyl)carbamoyl]phenyl}-3-cyano-6...)
Affinity DataIC50: 8nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320811(N-{4-[3-(beta-Alanylamino)phenyl]-6-(4-chloro-2-hy...)
Affinity DataIC50: 9.80nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320823(N-[4-{3-[(3-Amino-2,2-dimethylpropyl)carbamoyl]-ph...)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320813(N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(2-hyd...)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320815(N-(4-(3-(2-aminoethylcarbamoyl)phenyl)-3-cyano-6-(...)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320818(N-(4-(3-(1-amino-2-methylpropan-2-ylcarbamoyl)phen...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320812(N-{4-[3-(beta-Alanylamino)phenyl]-6-(4-bromo-2-hyd...)
Affinity DataIC50: 19nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320800(N-{4-[3-(b-Alanylamino)phenyl]-3-cyano-6-(2-hydrox...)
Affinity DataIC50: 21nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320804(N-[4-{3-[(2-Aminoethyl)carbamoyl]phenyl}-3-cyano-6...)
Affinity DataIC50: 30nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320817(N-(2-aminoethyl)-3-(3-cyano-6-(2-hydroxyphenyl)-2-...)
Affinity DataIC50: 31nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320820(N-(1-amino-2-methylpropan-2-yl)-3-(3-cyano-6-(2-hy...)
Affinity DataIC50: 32nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320819(N-(4-(3-(1-amino-2-methylpropan-2-ylcarbamoyl)phen...)
Affinity DataIC50: 32nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320802(N-[4-{3-[(4-Aminobutanoyl)amino]phenyl}-3-cyano-6-...)
Affinity DataIC50: 34nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320816(N-(4-(3-(2-aminoethylcarbamoyl)phenyl)-3-cyano-6-(...)
Affinity DataIC50: 45nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320801(N-{4-[3-(b-Alanylamino)phenyl]-3-cyano-6-(2-hydrox...)
Affinity DataIC50: 51nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320799(N-{3-Cyano-4-[3-(glycylamino)phenyl]-6-(2-hydroxyp...)
Affinity DataIC50: 51nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320814(N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(2-hyd...)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320805(N-[4-{4-[(2-Aminoethyl)carbamoyl]phenyl}-3-cyano-6...)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320821(N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(4-flu...)
Affinity DataIC50: 460nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320809(N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(2-hyd...)
Affinity DataIC50: 480nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320808(N-{4-[3-(beta-Alanylamino)phenyl]-6-(5-chloro-2-hy...)
Affinity DataIC50: 490nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320798(N-{4-[3-(Aminomethyl)phenyl]-3-cyano-6-(2-hydroxyp...)
Affinity DataIC50: 570nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320822(N-[4-{3-[(2-Aminoethyl)carbamoyl]phenyl}-3-cyano-6...)
Affinity DataIC50: 660nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320807(N-{4-[3-(beta-Alanylamino)phenyl]-6-(2-aminophenyl...)
Affinity DataIC50: 890nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320813(N-{4-[3-(beta-Alanylamino)phenyl]-3-cyano-6-(2-hyd...)
Affinity DataIC50: 910nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320800(N-{4-[3-(b-Alanylamino)phenyl]-3-cyano-6-(2-hydrox...)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320824(N-{4-[3-(b-Alanylamino)phenyl]-3-cyano-6-(2-hydrox...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320802(N-[4-{3-[(4-Aminobutanoyl)amino]phenyl}-3-cyano-6-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320795(N-(3-cyano-4-(3-(hydroxymethyl)phenyl)-6-(2-hydrox...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320797(N-[4-(3-Aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-p...)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320823(N-[4-{3-[(3-Amino-2,2-dimethylpropyl)carbamoyl]-ph...)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320799(N-{3-Cyano-4-[3-(glycylamino)phenyl]-6-(2-hydroxyp...)
Affinity DataIC50: 2.80E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320810(N-(4-(3-(3-aminopropanamido)phenyl)-3-cyano-6-(4-f...)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320811(N-{4-[3-(beta-Alanylamino)phenyl]-6-(4-chloro-2-hy...)
Affinity DataIC50: 4.10E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320804(N-[4-{3-[(2-Aminoethyl)carbamoyl]phenyl}-3-cyano-6...)
Affinity DataIC50: 5.10E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320812(N-{4-[3-(beta-Alanylamino)phenyl]-6-(4-bromo-2-hyd...)
Affinity DataIC50: 6.30E+3nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320796(3-{3-Cyano-6-(2-hydroxyphenyl)-2-[(thiophen-2-ylca...)
Affinity DataIC50: 9.90E+3nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320801(N-{4-[3-(b-Alanylamino)phenyl]-3-cyano-6-(2-hydrox...)
Affinity DataIC50: 2.40E+4nMAssay Description:Antagonist activity at human GPR54 receptor expressed in CHO cells assessed as inhibition of metastin(40-54)-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320806(N-[4-(3-Aminophenyl)-3-cyano-6-(2-methoxyphenyl)-p...)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetKiSS-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50320803(N-[4-{2-[(2-Aminoethyl)carbamoyl]phenyl}-3-cyano-6...)
Affinity DataIC50: 3.30E+4nMAssay Description:Displacement of [125I]metastin(40-54) from human GPR54 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed