Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50031749
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318345(5-benzyl-3-phenyloxazolidin-2-one | CHEMBL1095704)
Affinity DataEC50:  2.51E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318353(5-((4-ethylphenoxy)methyl)-3-phenyloxazolidin-2-on...)
Affinity DataEC50:  590nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318352(5-((3-ethylphenoxy)methyl)-3-phenyloxazolidin-2-on...)
Affinity DataEC50:  360nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318351(5-((2-ethylphenoxy)methyl)-3-phenyloxazolidin-2-on...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318350(3-phenyl-5-(p-tolyloxymethyl)oxazolidin-2-one | CH...)
Affinity DataEC50:  660nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318349(3-phenyl-5-(m-tolyloxymethyl)oxazolidin-2-one | CH...)
Affinity DataEC50:  3.44E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318348(3-phenyl-5-(o-tolyloxymethyl)oxazolidin-2-one | CH...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318347(5-((4-chlorophenoxy)methyl)-3-phenyloxazolidin-2-o...)
Affinity DataEC50:  360nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318346(5-(phenoxymethyl)-3-phenyloxazolidin-2-one | CHEMB...)
Affinity DataEC50:  3.50E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318354(5-((2-isopropylphenoxy)methyl)-3-phenyloxazolidin-...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318344(5-butyl-3-phenyloxazolidin-2-one | CHEMBL1095703)
Affinity DataEC50:  1.30E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318343(5-pentyl-3-phenyloxazolidin-2-one | CHEMBL1095702)
Affinity DataEC50:  790nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318342(5-octyl-3-phenyloxazolidin-2-one | CHEMBL1095701)
Affinity DataEC50:  1.20E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318312((R)-5-hexyl-3-phenyloxazolidin-2-one | CHEMBL10947...)
Affinity DataEC50:  590nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318341(5-hexyl-3-(4-(methylsulfonyl)phenyl)oxazolidin-2-o...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318340(5-hexyl-3-(3-(methylsulfonyl)phenyl)oxazolidin-2-o...)
Affinity DataEC50:  2.70E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318339(5-hexyl-3-(2-(methylsulfonyl)phenyl)oxazolidin-2-o...)
Affinity DataEC50: >3.00E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318338(methyl 4-(5-hexyl-2-oxooxazolidin-3-yl)benzoate | ...)
Affinity DataEC50:  1.22E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318355(5-((3-isopropylphenoxy)methyl)-3-phenyloxazolidin-...)
Affinity DataEC50:  580nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318356(5-((4-isopropylphenoxy)methyl)-3-phenyloxazolidin-...)
Affinity DataEC50:  360nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318357(5-((3-tert-butylphenoxy)methyl)-3-phenyloxazolidin...)
Affinity DataEC50:  350nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318358(5-[(4-tert-butylphenoxy)methyl]-3-phenyl-1,3-oxazo...)
Affinity DataEC50:  240nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318359(5-((2-methoxyphenoxy)methyl)-3-phenyloxazolidin-2-...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318360(5-((3-methoxyphenoxy)methyl)-3-phenyloxazolidin-2-...)
Affinity DataEC50:  4.11E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318361(5-((4-methoxyphenoxy)methyl)-3-phenyloxazolidin-2-...)
Affinity DataEC50:  2.19E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318362(5-((2-chlorophenoxy)methyl)-3-phenyloxazolidin-2-o...)
Affinity DataEC50:  3.90E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318363(5-((3-chlorophenoxy)methyl)-3-phenyloxazolidin-2-o...)
Affinity DataEC50:  840nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318364(3-phenyl-5-((2-(trifluoromethyl)phenoxy)methyl)oxa...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318365(3-phenyl-5-((3-(trifluoromethyl)phenoxy)methyl)oxa...)
Affinity DataEC50:  1.18E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318366(3-phenyl-5-((4-(trifluoromethyl)phenoxy)methyl)oxa...)
Affinity DataEC50:  780nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318367(5-((3-aminophenoxy)methyl)-3-phenyloxazolidin-2-on...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318368(5-((4-aminophenoxy)methyl)-3-phenyloxazolidin-2-on...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318369(3-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)benzamid...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318322(3-(3-chlorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Affinity DataEC50:  590nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318309(N-(2-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)pheny...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318310(N-(3-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)pheny...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318311(N-(4-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)pheny...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318312((R)-5-hexyl-3-phenyloxazolidin-2-one | CHEMBL10947...)
Affinity DataEC50:  450nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318313(3-{(5S)-5-[(4-tert-butylphenoxy)methyl]-2-oxo-1,3-...)
Affinity DataEC50:  82nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318312((R)-5-hexyl-3-phenyloxazolidin-2-one | CHEMBL10947...)
Affinity DataEC50:  1.38E+4nMAssay Description:Agonist activity at human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318313(3-{(5S)-5-[(4-tert-butylphenoxy)methyl]-2-oxo-1,3-...)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318314((R)-3-(5-((4-tert-butylphenoxy)methyl)-2-oxooxazol...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318315(5-hexyl-3-o-tolyloxazolidin-2-one | CHEMBL1096081)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318316(5-hexyl-3-m-tolyloxazolidin-2-one | CHEMBL1096423)
Affinity DataEC50:  640nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318317(5-hexyl-3-p-tolyloxazolidin-2-one | CHEMBL1095638)
Affinity DataEC50:  3.82E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318318(3-(2-fluorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Affinity DataEC50:  7.15E+3nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318319(3-(3-fluorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Affinity DataEC50:  640nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318320(3-(4-fluorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Affinity DataEC50:  790nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318321(3-(2-chlorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50318308(4-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)benzamid...)
Affinity DataEC50: >3.00E+4nMAssay Description:Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
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