Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50039152
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataEC50:  4.91E+5nMAssay Description:Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataEC50:  4.89E+5nMAssay Description:Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataEC50:  4.30E+4nMAssay Description:Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataEC50:  4.30E+4nMAssay Description:Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.40E+4nMAssay Description:Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataIC50: 2.45E+5nMAssay Description:Antagonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as inhibition of (S)-Glu-induced intracellular calcium levels by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataIC50: 2.45E+5nMAssay Description:Antagonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as inhibition of (S)-Glu-induced intracellular calcium levels by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataIC50: 1.02E+6nMAssay Description:Antagonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as inhibition of (S)-Glu-induced intracellular calcium levels by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataIC50: 1.02E+6nMAssay Description:Antagonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as inhibition of (S)-Glu-induced intracellular calcium levels by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  280nMAssay Description:Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi:  8.10E+3nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi:  8.10E+3nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi:  2.00E+4nMAssay Description:Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataKi:  4.00E+4nMAssay Description:Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataKi:  4.10E+4nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataKi:  5.30E+4nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi:  6.70E+4nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318265((+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)buta...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50318266((+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pent...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed