Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50031544
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315095(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315097(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315088(4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-tri...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315087(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315096((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315082((R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315090((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315085(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315091((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315093((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315099(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315086(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315098(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315092((R)-1-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315083(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315084(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 2nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315089((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315094(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315088(4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-tri...)
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315093((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315087(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 55nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315086(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 76nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315082((R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315097(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 173nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315089((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 220nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315091((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 269nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315083(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 287nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315085(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 314nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315099(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 330nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315092((R)-1-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-...)
Affinity DataIC50: 402nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315084(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 413nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315090((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 414nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315096((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50: 593nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315095(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 644nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315098(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50: 846nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315094(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed