Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50031441
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313364((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313371((2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313374((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313367((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313384((2S,3R,4R,5S,6S)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313368((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313375((5S,6R,7R,8S)-5-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313377((6S,7R,8R,9S)-6-[3-(4-Ethyl-benzyl)-4-methyl-pheny...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313381((2S,3R,4S,6S)-2-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313369((6S,7R,8R,9S)-6-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313370((6S,7R,8R,9S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313373((5R,7S,8R,9R,10S)-7-(3-(4-ethylbenzyl)-4-methylphe...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313372((3S,4R,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313371((2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50: 73nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313382((2S,3R,4R,5R,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Affinity DataIC50: 139nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313378((2R,3S,4S,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313383((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313374((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469(CHEMBL589305 | CHEMBL3125314 | CHEMBL3125459 | CHE...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313375((5S,6R,7R,8S)-5-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313365((2R,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylbenz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313373((5R,7S,8R,9R,10S)-7-(3-(4-ethylbenzyl)-4-methylphe...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313367((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313368((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313379((2S,3R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313380((2S,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313376((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313370((6S,7R,8R,9S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313372((3S,4R,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313369((6S,7R,8R,9S)-6-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313377((6S,7R,8R,9S)-6-[3-(4-Ethyl-benzyl)-4-methyl-pheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313376((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313366((2R,3S,4R,6R)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed