Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50031427
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313095(4-chloro-3-(1-(2-chlorophenyl)-1H-pyrazolo[4,3-d]p...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313114(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313116(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313106(N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1H-pyrazol...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313105(4-chloro-N-cyclopropyl-3-(1-(2,5-difluorophenyl)-1...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313110(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-met...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313112(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7-methyl-1...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313100(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1H-pyrazol...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313108(N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1H-pyrazol...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313102(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313109(N-cyclopropyl-3-(1-(4-fluorophenyl)-7-methyl-1H-py...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313096(N-cyclopropyl-3-(1-(3-fluorophenyl)-1H-pyrazolo[4,...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313097(4-chloro-N-cyclopropyl-3-(1-(3-fluorophenyl)-1H-py...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313115(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7-methyl-1...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313111(N-cyclopropyl-3-(1-(4-fluorophenyl)-7-methyl-1H-py...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313098(4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-1H-py...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313103(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1H-pyrazol...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313113(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7-methyl-1...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313099(3-(1-(2,4-difluorophenyl)-1H-pyrazolo[4,3-d]pyrida...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313104(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313101(N-cyclopropyl-3-(1-(2,4-difluorophenyl)-1H-pyrazol...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed