Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50031088
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306740(Isopropyl 1,1-Dimethyl-3-[4-(morpholin-4-ylmethyl)...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306714(Isopropyl 1,1-Dimethyl-3-[4-(3-morpholin-4-ylpropo...)
Affinity DataEC50:  101nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306734(isopropyl 3-(3,4-difluorobenzoyl)-9-fluoro-1,1-dim...)
Affinity DataEC50:  112nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306735(1-methylethyl 8-fluoro-1,1-dimethyl-3-{[4-(3-morph...)
Affinity DataEC50:  88nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28542(propan-2-yl 3-[(3,4-difluorophenyl)carbonyl]-1,1-d...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306734(isopropyl 3-(3,4-difluorobenzoyl)-9-fluoro-1,1-dim...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306736(Isopropyl 1,1-Dimethyl-3-[3-(morpholin-4-ylmethyl)...)
Affinity DataEC50:  1.58E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306737(Isopropyl 1,1-Dimethyl-3-{3-[(4-methylpiperazin-1-...)
Affinity DataEC50:  368nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306738(Isopropyl 1,1-Dimethyl-3-[3-(piperidin-1-ylmethyl)...)
Affinity DataEC50:  534nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306739(Isopropyl 1,1-Dimethyl-3-[3-(pyrrolidin-1-ylmethyl...)
Affinity DataEC50:  340nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28542(propan-2-yl 3-[(3,4-difluorophenyl)carbonyl]-1,1-d...)
Affinity DataEC50:  152nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306741(Isopropyl 8-Fluoro-1,1-dimethyl-3-[4-(morpholin-4-...)
Affinity DataEC50:  447nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306742(Isopropyl 1,1-Dimethyl-3-[4-(2-morpholin-4-ylethyl...)
Affinity DataEC50:  602nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306743(Isopropyl 8-Fluoro-1,1-dimethyl-3-[4-(2-morpholin-...)
Affinity DataEC50:  342nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306735(1-methylethyl 8-fluoro-1,1-dimethyl-3-{[4-(3-morph...)
Affinity DataEC50:  52nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306744(Isopropyl 8-Fluoro-1,1-dimethyl-3-[4-(2-morpholin-...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306744(Isopropyl 8-Fluoro-1,1-dimethyl-3-[4-(2-morpholin-...)
Affinity DataEC50:  188nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306714(Isopropyl 1,1-Dimethyl-3-[4-(3-morpholin-4-ylpropo...)
Affinity DataEC50:  108nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306718(Isopropyl 1,1-Dimethyl-3-[4-(2-morpholin-4-ylethox...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306722(Isopropyl 1,1-Dimethyl-3-[4-(3-piperidin-1-ylpropo...)
Affinity DataEC50:  424nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306715(Isopropyl 1,1-Dimethyl-3-[4-(2-piperidin-1-ylethox...)
Affinity DataEC50:  1.07E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306716(Isopropyl 3-{4-[2-(Dimethylamino)ethoxy]benzoyl}-1...)
Affinity DataEC50:  439nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306717(Isopropyl 1,1-Dimethyl-3-[4-(2-pyrrolidin-1-yletho...)
Affinity DataEC50:  698nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306718(Isopropyl 1,1-Dimethyl-3-[4-(2-morpholin-4-ylethox...)
Affinity DataEC50:  249nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306719(Isopropyl 1,1-Dimethyl-3-{4-[2-(4-methylpiperazin-...)
Affinity DataEC50:  287nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306720(Isopropyl 3-{4-[3-(Dimethylamino)propoxy]benzoyl}-...)
Affinity DataEC50:  271nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306721(Isopropyl 1,1-Dimethyl-3-[4-(3-pyrrolidin-1-ylprop...)
Affinity DataEC50:  362nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306733(Isopropyl 1,1-Dimethyl-3-{3-[3-(4-methylpiperazin-...)
Affinity DataEC50:  1.02E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306723(Isopropyl 1,1-Dimethyl-3-{4-[3-(4-methylpiperazin-...)
Affinity DataEC50:  194nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306724(Isopropyl 3-{3-[2-(Dimethylamino)ethoxy]benzoyl}-1...)
Affinity DataEC50:  1.39E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306725(Isopropyl 1,1-Dimethyl-3-[3-(2-pyrrolidin-1-yletho...)
Affinity DataEC50:  1.32E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306726(Isopropyl 1,1-Dimethyl-3-[3-(2-piperidin-1-ylethox...)
Affinity DataEC50:  894nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306727(Isopropyl 1,1-Dimethyl-3-[3-(2-morpholin-4-ylethox...)
Affinity DataEC50:  855nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306728(Isopropyl 1,1-Dimethyl-3-{3-[2-(4-methylpiperazin-...)
Affinity DataEC50:  2.87E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306729(Isopropyl 3-{3-[3-(Dimethylamino)propoxy]benzoyl}-...)
Affinity DataEC50:  617nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306730(Isopropyl 1,1-Dimethyl-3-[3-(3-pyrrolidin-1-ylprop...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306731(Isopropyl 1,1-Dimethyl-3-[3-(3-piperidin-1-ylpropo...)
Affinity DataEC50:  1.12E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306732(Isopropyl 1,1-Dimethyl-3-[3-(3-morpholin-4-ylpropo...)
Affinity DataEC50:  796nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50306714(Isopropyl 1,1-Dimethyl-3-[4-(3-morpholin-4-ylpropo...)
Affinity DataIC50: 5.74E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50306735(1-methylethyl 8-fluoro-1,1-dimethyl-3-{[4-(3-morph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
LigandPNGBDBM50306744(Isopropyl 8-Fluoro-1,1-dimethyl-3-[4-(2-morpholin-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed