Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50031391
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312541(((S)-1-[(S)-1-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl...)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312539(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312537(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312538(N-[(2S,3S,5R)-1-[(3,5-difluorophenyl)methoxy]-3-hy...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312540(N-[(1S,2S,4S)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312537(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312539(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312540(N-[(1S,2S,4S)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312539(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312538(N-[(2S,3S,5R)-1-[(3,5-difluorophenyl)methoxy]-3-hy...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312540(N-[(1S,2S,4S)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 340nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312537(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312542(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312544(N-[(1S,2S,4R)-1-(3,5-Difluoro-benzyloxymethyl)-4-(...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312538(N-[(2S,3S,5R)-1-[(3,5-difluorophenyl)methoxy]-3-hy...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human BACE1 in HEK293 cells stably co-transfected with mutant APP(swAPP751) assessed as Amyloid beta 1-40 level after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312543(N-((1S,2S,4R)-1-Benzyloxymethyl-4-cyclopropylcarba...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312544(N-[(1S,2S,4R)-1-(3,5-Difluoro-benzyloxymethyl)-4-(...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312542(N-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl-2-methylpro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312543(N-((1S,2S,4R)-1-Benzyloxymethyl-4-cyclopropylcarba...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50312541(((S)-1-[(S)-1-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 30 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed