Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50031223
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309241((R)-6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbon...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309229(6-(3-(4-(2-(dimethylamino)-2-methylpropanoyl)piper...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309249(6-(3-(4-(2-allylpyrrolidine-2-carbonyl)piperazine-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309234(6-(3-(4-(1-(cyclopropylmethylamino)cyclopentanecar...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309253((R)-6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidin...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309221(6,7-dichloro-4-(4-fluoro-3-(1,8-diazaspiro[4.5]dec...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309223(6-(4-fluoro-3-(1,8-diazaspiro[4.5]decane-8-carbony...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309243((R)-6-(4-fluoro-3-(4-(pyrrolidine-2-carbonyl)piper...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309232(6-(4-fluoro-3-(4-(1-(methylamino)cyclopentanecarbo...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309235(6-(4-fluoro-3-(4-(1-(pyrrolidin-1-yl)cyclopentanec...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309244(6-(4-fluoro-3-(4-(2-methyltetrahydrofuran-2-carbon...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309239(6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbonyl)p...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309247((R)-6-(4-fluoro-3-(4-(2-methylazetidine-2-carbonyl...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309242((S)-6-(4-fluoro-3-(4-(pyrrolidine-2-carbonyl)piper...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309233(6-(3-(4-(1-(ethylamino)cyclopentanecarbonyl)pipera...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309238(6-(3-(4-(1-(cyclopropylmethylamino)cyclobutanecarb...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309250(6-(3-(4-(2-benzylpyrrolidine-2-carbonyl)piperazine...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309237(6-(3-(4-(1-(cyclopropylmethylamino)cyclohexanecarb...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309230(6-(4-fluoro-3-(4-(1-(methylamino)cyclopropanecarbo...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309251(6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidine-2-...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309228(6-(4-fluoro-3-(4-(2-methyl-2-(methylamino)propanoy...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309240((S)-6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbon...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309248(6-(3-(4-(2-ethylpyrrolidine-2-carbonyl)piperazine-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309236(6-(4-fluoro-3-(4-(1-(phenylamino)cyclopentanecarbo...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309245(6-(4-fluoro-3-(4-(pyrrolidine-3-carbonyl)piperazin...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309252((S)-6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidin...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309224(6-(4-fluoro-3-(1-methyl-1,8-diazaspiro[4.5]decane-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309227(6-(4-fluoro-3-(1,7-diazaspiro[3.5]nonane-7-carbony...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309226(6-(4-fluoro-3-(2,8-diazaspiro[4.5]decane-8-carbony...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309231(6-(3-(4-(1-(dimethylamino)cyclopropanecarbonyl)pip...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309225(6-(3-(1-ethyl-1,8-diazaspiro[4.5]decane-8-carbonyl...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309246(6-(4-fluoro-3-(4-(2-methylpiperidine-2-carbonyl)pi...)
Affinity DataIC50: 12nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309221(6,7-dichloro-4-(4-fluoro-3-(1,8-diazaspiro[4.5]dec...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed