Compile Data Set for Download or QSAR
Report error Found 112 Enz. Inhib. hit(s) with all data for entry = 50041777
TargetMetabotropic glutamate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Agonist activity at mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Antagonist activity at mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Agonist activity at mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Antagonist activity at mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50: >1.58E+4nMAssay Description:Positive modulation of mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415268(CHEMBL595607)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415269(CHEMBL595608)
Affinity DataEC50:  200nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415270(CHEMBL595609)
Affinity DataEC50:  316nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415271(CHEMBL595151)
Affinity DataEC50:  501nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415272(CHEMBL339714)
Affinity DataEC50:  1.58E+4nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415273(CHEMBL595761)
Affinity DataEC50: >1.26E+4nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415274(CHEMBL594011)
Affinity DataEC50:  63.1nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415275(CHEMBL607195)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415276(CHEMBL594236)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415277(CHEMBL594204)
Affinity DataEC50:  158nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415278(CHEMBL604472)
Affinity DataEC50:  158nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415279(CHEMBL594205)
Affinity DataEC50:  501nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415280(CHEMBL594428)
Affinity DataEC50:  794nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343298(1-Methyl-2-((4-phenylpiperidin-1-yl)methyl)-1H-ben...)
Affinity DataEC50:  200nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415281(CHEMBL593744)
Affinity DataEC50:  79.4nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343307(1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  316nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415282(CHEMBL604993)
Affinity DataEC50:  100nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343306(1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  100nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415283(CHEMBL608103)
Affinity DataEC50:  100nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415284(CHEMBL605831)
Affinity DataEC50:  158nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415285(CHEMBL596527)
Affinity DataEC50:  200nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415286(CHEMBL593056)
Affinity DataEC50:  39.8nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415287(CHEMBL608979)
Affinity DataEC50: >3.16E+3nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415288(CHEMBL593300)
Affinity DataEC50:  5.01E+3nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415289(CHEMBL596270)
Affinity DataEC50:  794nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM71863(2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-met...)
Affinity DataEC50:  794nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415290(CHEMBL603443)
Affinity DataEC50:  316nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415291(GSK-1331258 | CHEMBL605836)
Affinity DataEC50:  79.4nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415292(GSK-1331268 | CHEMBL595759)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415293(CHEMBL607311)
Affinity DataEC50:  2.51E+3nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415294(CHEMBL595991)
Affinity DataEC50:  1.26E+4nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415295(CHEMBL594673)
Affinity DataEC50:  1.26E+4nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415296(CHEMBL604469)
Affinity DataEC50:  251nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415297(CHEMBL593755)
Affinity DataEC50:  50.1nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415298(CHEMBL593756)
Affinity DataEC50:  2.00E+3nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415299(CHEMBL593532)
Affinity DataEC50:  126nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415300(CHEMBL607313)
Affinity DataEC50:  200nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343298(1-Methyl-2-((4-phenylpiperidin-1-yl)methyl)-1H-ben...)
Affinity DataEC50:  6.31E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415281(CHEMBL593744)
Affinity DataEC50:  5.01E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343307(1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  6.31E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415282(CHEMBL604993)
Affinity DataEC50:  2.51E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50343306(1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415283(CHEMBL608103)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
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