Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50030684
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300114((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 16.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300116((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 25.7nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataIC50: 28.3nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300115((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 32.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300118((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 32.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300117((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataIC50: 56nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300122((11S,14S,20S,23S,26S)-11-benzyl-23-((6-chloro-1H-i...)
Affinity DataIC50: 140nMAssay Description:Binding affinity to his-tagged human recombinant MDM2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataIC50: 157nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300121(US8680132, MI- 219 | CHEMBL572933 | (2'R,3S,4'R,5'...)
Affinity DataIC50: 162nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300120((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataIC50: 189nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300114((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300115((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300116((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataKi:  1.70nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300118((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  2nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300117((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  12.6nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300121(US8680132, MI- 219 | CHEMBL572933 | (2'R,3S,4'R,5'...)
Affinity DataKi:  13.1nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50300120((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  15.4nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed