Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50030665
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50025671(CHEMBL583413)
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50025671(CHEMBL583413)
Affinity DataIC50: 3.00E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299820((+/-)-syn-6,7-Bis(4-bromophenyl)-1-ethoxy-12-methy...)
Affinity DataIC50: 6.50E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299822((+/-)-syn-6,7-Bis(4-chlorophenyl)-12-methyl-7,12-d...)
Affinity DataIC50: 9.37E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299818((+/-)-syn-6,7-Bis(4-bromophenyl)-3-fluoro-2,12-dim...)
Affinity DataIC50: 1.14E+4nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299821((+/-)-syn-7-(4-Bromophenyl)-6-(4-chlorophenyl)-12-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299819((+/-)-syn-6,7-Bis(4-bromophenyl)-2-fluoro-12-methy...)
Affinity DataIC50: 4.43E+4nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299823((6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chr...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ligase activity of human MDM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed