Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 3479
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35317(CHEMBL212964 | 4-Methyl-3-(2-(methylamino)quinazol...)
Affinity DataIC50: 0.270nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM14971(4-methyl-3-{[3-(pyrimidin-4-yl)pyridin-2-yl]amino}...)
Affinity DataIC50: 0.460nM EC50:  15nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35317(CHEMBL212964 | 4-Methyl-3-(2-(methylamino)quinazol...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50: 1.60nM EC50:  1.80nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35317(CHEMBL212964 | 4-Methyl-3-(2-(methylamino)quinazol...)
Affinity DataIC50: 1.70nM EC50:  27nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35317(CHEMBL212964 | 4-Methyl-3-(2-(methylamino)quinazol...)
Affinity DataIC50: 1.80nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35319(aminoisoquinoline, 12b)
Affinity DataIC50: 3.40nM EC50:  34nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM14971(4-methyl-3-{[3-(pyrimidin-4-yl)pyridin-2-yl]amino}...)
Affinity DataIC50: 3.5nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35317(CHEMBL212964 | 4-Methyl-3-(2-(methylamino)quinazol...)
Affinity DataIC50: 3.5nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM14971(4-methyl-3-{[3-(pyrimidin-4-yl)pyridin-2-yl]amino}...)
Affinity DataIC50: 3.60nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM14971(4-methyl-3-{[3-(pyrimidin-4-yl)pyridin-2-yl]amino}...)
Affinity DataIC50: 4.20nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35324(aminoquinazoline, 18)
Affinity DataIC50: 5.40nM EC50:  270nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35323(aminoisoquinoline, 16)
Affinity DataIC50: 5.80nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 8.10nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35320(aminoisoquinoline, 13)
Affinity DataIC50: 12nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM14971(4-methyl-3-{[3-(pyrimidin-4-yl)pyridin-2-yl]amino}...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50: 17nM EC50:  53nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 18nM EC50:  26nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35326(aminoquinazoline, 20)
Affinity DataIC50: 21nM EC50:  27nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 21nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35323(aminoisoquinoline, 16)
Affinity DataIC50: 23nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35320(aminoisoquinoline, 13)
Affinity DataIC50: 24nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35321(aminoisoquinoline, 14)
Affinity DataIC50: 39nM EC50:  44nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50: 47nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35326(aminoquinazoline, 20)
Affinity DataIC50: 51nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35320(aminoisoquinoline, 13)
Affinity DataIC50: 56nM EC50:  35nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 70nM EC50:  22nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35326(aminoquinazoline, 20)
Affinity DataIC50: 78nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50: 81nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50: 83nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35324(aminoquinazoline, 18)
Affinity DataIC50: 110nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35323(aminoisoquinoline, 16)
Affinity DataIC50: 110nM EC50:  29nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35327(pyridylpurine aminoisoquinoline, 1)
Affinity DataIC50: 120nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35321(aminoisoquinoline, 14)
Affinity DataIC50: 150nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35323(aminoisoquinoline, 16)
Affinity DataIC50: 170nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 200nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 210nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35325(aminoquinazoline, 19)
Affinity DataIC50: 230nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35326(aminoquinazoline, 20)
Affinity DataIC50: 240nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35319(aminoisoquinoline, 12b)
Affinity DataIC50: 280nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35320(aminoisoquinoline, 13)
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35323(aminoisoquinoline, 16)
Affinity DataIC50: 350nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35321(aminoisoquinoline, 14)
Affinity DataIC50: 400nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 420nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35322(aminoisoquinoline, 15)
Affinity DataIC50: 450nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35319(aminoisoquinoline, 12b)
Affinity DataIC50: 520nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50: 760nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
LigandPNGBDBM35321(aminoisoquinoline, 14)
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35326(aminoquinazoline, 20)
Affinity DataIC50: 1.00E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2009
Entry Details Article
PubMed
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