Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50030734
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300671(2-(5-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300666(2-{6-[(2-Naphthylsulfonyl)amino]-2,3-dihydro-1H-in...)
Affinity DataIC50: 53nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300673(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300670((+/-)-2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5...)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300669(2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300674(6-chloro-N-[3-(4,5-dihydro-1H-imidazol-2-ylhydrazo...)
Affinity DataIC50: 176nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300672(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 238nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300667(2-(6-{[(4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-...)
Affinity DataIC50: 581nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300673(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300667(2-(6-{[(4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300666(2-{6-[(2-Naphthylsulfonyl)amino]-2,3-dihydro-1H-in...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300670((+/-)-2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300672(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300670((+/-)-2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300670((+/-)-2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300672(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM34156(indenylsulfonamide, 28)
Affinity DataIC50: 1.58E+3nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as inhibition of 5-HT-stimulated cAMP production after 30 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300669(2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300671(2-(5-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300669(2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300674(6-chloro-N-[3-(4,5-dihydro-1H-imidazol-2-ylhydrazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300669(2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300672(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300674(6-chloro-N-[3-(4,5-dihydro-1H-imidazol-2-ylhydrazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300675(2-(1-(5-(phenylsulfonamido)-1H-indol-3-yl)ethylide...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300676(2-(1-(5-(4-methoxyphenylsulfonamido)-1H-indol-3-yl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300669(2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300670((+/-)-2-(6-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300674(6-chloro-N-[3-(4,5-dihydro-1H-imidazol-2-ylhydrazo...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM34152(CHEMBL362628 | E-6801)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300671(2-(5-{[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM34156(indenylsulfonamide, 28)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300673(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300672(2-(6-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)su...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300667(2-(6-{[(4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300666(2-{6-[(2-Naphthylsulfonyl)amino]-2,3-dihydro-1H-in...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50300668(N-[3-(4,5-dihydro-1H-imidazol-2-ylhydrazono-2,3-di...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed