Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50030808
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301816(2-cyclopropyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301821(2-ethyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,...)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301824(2-cyclopropyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301822(CHEMBL568443 | CHEMBL1645349 | 5-(1-(2-fluoropyrid...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at rat mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301818(6-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl...)
Affinity DataIC50: 4.90nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301823(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273942(CHEMBL502882 | CHEMBL1645350 | 4-[1-(2-Fuluoropyri...)
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301815(2,2-dimethyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301807(cyclopropyl(4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301809(isopropyl 4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-tr...)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301814(5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl...)
Affinity DataIC50: 69nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301806(1-(4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301811(N-isopropyl-4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-...)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301817(5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301819(3-(5-methyl-4-(naphthalen-2-yl)-1H-1,2,3-triazol-1...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301805(1-(4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4...)
Affinity DataIC50: 470nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301812(N-isopropyl-N-methyl-4-(5-methyl-1-(pyridin-3-yl)-...)
Affinity DataIC50: 880nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301821(2-ethyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,...)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301820(2-methyl-5-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-tri...)
Affinity DataIC50: 1.50E+3nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301813((4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-y...)
Affinity DataIC50: 1.80E+3nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301823(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50: 2.30E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301810(isopropyl 3-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-tr...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301822(CHEMBL568443 | CHEMBL1645349 | 5-(1-(2-fluoropyrid...)
Affinity DataIC50: 2.80E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301808((4-(5-methyl-1-(pyridin-3-yl)-1H-1,2,3-triazol-4-y...)
Affinity DataIC50: 3.90E+3nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301824(2-cyclopropyl-5-(1-(2-fluoropyridin-3-yl)-5-methyl...)
Affinity DataIC50: 5.40E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR1 receptor quisqualic acid binding site expressed in CHO cell membranes assessed as inhibition of L-glutamate-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR8 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50273942(CHEMBL502882 | CHEMBL1645350 | 4-[1-(2-Fuluoropyri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed