Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50030764
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-...)
Affinity DataEC50:  2.40nMAssay Description:Inverse agonist activity at human CB1 receptor assessed as forskolin-induced cAMP level by adenylyl cyclase activation flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301027(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataEC50:  3.20nMAssay Description:Inverse agonist activity at human CB1 receptor assessed as forskolin-induced cAMP level by adenylyl cyclase activation flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301030(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataEC50:  0.900nMAssay Description:Inverse agonist activity at human CB1 receptor assessed as forskolin-induced cAMP level by adenylyl cyclase activation flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301042(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataEC50:  1.90nMAssay Description:Inverse agonist activity at human CB1 receptor assessed as forskolin-induced cAMP level by adenylyl cyclase activation flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301037(2-(5-tert-butylisoxazol-3-ylamino)-N-((2S,3S)-4-(4...)
Affinity DataEC50:  3.5nMAssay Description:Inverse agonist activity at human CB1 receptor assessed as forskolin-induced cAMP level by adenylyl cyclase activation flash plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301030(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301027(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 7.5nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301037(2-(5-tert-butylisoxazol-3-ylamino)-N-((2S,3S)-4-(4...)
Affinity DataIC50: 8.60nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301042(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 10.1nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301028(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 12.2nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301029(2-(3-chloro-5-(trifluoromethyl)pyridin-2-ylamino)-...)
Affinity DataIC50: 17.9nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301036(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 19.5nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301031(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 37.7nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301034(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 46.1nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301035(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 47.7nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301032(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 49nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301033(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 49.2nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301041(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 97nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301042(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 117nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301044(2-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 132nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301045(2-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 136nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301038(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 186nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301040(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 203nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301038(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 234nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301037(2-(5-tert-butylisoxazol-3-ylamino)-N-((2S,3S)-4-(4...)
Affinity DataIC50: 254nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-...)
Affinity DataIC50: 285nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301039(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 301nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301027(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 322nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301030(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 353nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301029(2-(3-chloro-5-(trifluoromethyl)pyridin-2-ylamino)-...)
Affinity DataIC50: 419nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301031(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 547nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301028(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 699nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301041(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 1.41E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301044(2-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 1.72E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301032(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 1.83E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301027(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301045(2-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 2.31E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301043(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 2.98E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301035(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 3.21E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301034(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 3.86E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301036(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 5.16E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301039(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 6.11E+3nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301040(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 1.33E+4nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301033(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 1.40E+4nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301043(N-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 2.59E+4nMAssay Description:Displacement of [3H]CP-55940 from recombinant human CB2 receptor expressed in CHO cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301044(2-((2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)but...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed