Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50030506
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10324(tert-butyl 2-(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10326((S)-1-(4-Pyridinylmethyl)-5-{1-[2-(phenoxymethyl)p...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10321((S)-1-Allyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]su...)
Affinity DataIC50: 5nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10322(1-(cyclohexylmethyl)-5-{[(2S)-2-(phenoxymethyl)pyr...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10315(5-{[(2S)-2-[(phenylamino)methyl]pyrrolidine-1-]sul...)
Affinity DataIC50: 31nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10319(5-{[(2S)-2-[(phenylsulfanyl)methyl]pyrrolidine-1-]...)
Affinity DataIC50: 44nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10318(5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}...)
Affinity DataIC50: 44nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10313(tert-butyl (2S)-1-[(2,3-dioxo-2,3-dihydro-1H-indol...)
Affinity DataIC50: 70nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataIC50: 120nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10325(2-(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)pyrrolidine...)
Affinity DataIC50: 170nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10312(methyl (2S)-1-[(2,3-dioxo-2,3-dihydro-1H-indole-5-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10308(5-[1-(Azetidinyl)sulfonyl]isatin | 5-(azetidine-1-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10314((S)-5-(1-{[2-(Dimethylamino)carbonyl]pyrrolidinyl}...)
Affinity DataIC50: 410nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10307(5-{1-[(2-Methoxyethyl)methylamino]sulfonyl}isatin ...)
Affinity DataIC50: 910nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10311(5-(azepane-1-sulfonyl)-2,3-dihydro-1H-indole-2,3-d...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10310(5-(piperidine-1-sulfonyl)-2,3-dihydro-1H-indole-2,...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10309(5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCaspase-3(Human)
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM50297258(5-(2-((methyl(phenyl)amino)methyl)pyrrolidin-1-yls...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed