Compile Data Set for Download or QSAR
Report error Found 176 Enz. Inhib. hit(s) with all data for entry = 50030495
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297081((S)-N-(cyclobutylmethyl)-2-phenoxy-N-(pyrrolidin-3...)
Affinity DataIC50: 65nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297087((S)-N-isobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benzam...)
Affinity DataIC50: 290nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297080((S)-N-(cyclobutylmethyl)-2-cyclopentyl-N-(pyrrolid...)
Affinity DataIC50: 430nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297078((S)-N-(cyclobutylmethyl)-2-(ethylthio)-N-(pyrrolid...)
Affinity DataIC50: 480nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297081((S)-N-(cyclobutylmethyl)-2-phenoxy-N-(pyrrolidin-3...)
Affinity DataIC50: 760nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297087((S)-N-isobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benzam...)
Affinity DataIC50: 1.08E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262678((S)-ethyl biphenyl-2-ylmethyl(pyrrolidin-3-yl)carb...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297089((S)-N-isobutyl-N-(pyrrolidin-3-yl)biphenyl-2-carbo...)
Affinity DataIC50: 1.44E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297080((S)-N-(cyclobutylmethyl)-2-cyclopentyl-N-(pyrrolid...)
Affinity DataIC50: 2.21E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297098((S)-N-cyclohexyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataIC50: 2.27E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297106((S)-N-(cyclopentylmethyl)-2-isopropyl-N-(pyrrolidi...)
Affinity DataIC50: 2.35E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297088((S)-2-phenoxy-N-phenyl-N-(pyrrolidin-3-yl)benzamid...)
Affinity DataIC50: 2.81E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297086((S)-N-cyclobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benz...)
Affinity DataIC50: 2.95E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297083((S)-N-phenyl-N-(pyrrolidin-3-yl)-2-(trifluoromethy...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50262415(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-isobut...)
Affinity DataIC50: 3.02E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297079((S)-N-(cyclobutylmethyl)-2-isopropyl-N-(pyrrolidin...)
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297086((S)-N-cyclobutyl-2-phenoxy-N-(pyrrolidin-3-yl)benz...)
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50262678((S)-ethyl biphenyl-2-ylmethyl(pyrrolidin-3-yl)carb...)
Affinity DataIC50: 4.98E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297085((S)-N-ethyl-2-phenoxy-N-(pyrrolidin-3-yl)benzamide...)
Affinity DataIC50: 5.03E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297088((S)-2-phenoxy-N-phenyl-N-(pyrrolidin-3-yl)benzamid...)
Affinity DataIC50: 5.54E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297112((S)-N-(pyrrolidin-3-yl)-N-(2-(trifluoromethyl)benz...)
Affinity DataIC50: 7.46E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297078((S)-N-(cyclobutylmethyl)-2-(ethylthio)-N-(pyrrolid...)
Affinity DataIC50: 7.57E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297107((S)-N-methyl-2-phenoxy-N-(pyrrolidin-3-yl)benzamid...)
Affinity DataIC50: 9.21E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297100((S)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-(trifluorom...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50236389(N-methyl-1-(6-methyl-4-(2-phenoxyphenoxy)pyridin-3...)
Affinity DataIC50: 1.12E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297102((S)-N-(cyclopentylmethyl)-N-(pyrrolidin-3-yl)-2-(t...)
Affinity DataIC50: 1.35E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297094((S)-N-(cyclobutylmethyl)-2-ethyl-N-(pyrrolidin-3-y...)
Affinity DataIC50: 1.63E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297092((S)-N-(cyclobutylmethyl)-2-ethoxy-N-(pyrrolidin-3-...)
Affinity DataIC50: 1.68E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297104((S)-N-(cyclopropylmethyl)-2-isopropyl-N-(pyrrolidi...)
Affinity DataIC50: 1.76E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297079((S)-N-(cyclobutylmethyl)-2-isopropyl-N-(pyrrolidin...)
Affinity DataIC50: 1.82E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297084((S)-N-cyclopentyl-2-isopropyl-N-(pyrrolidin-3-yl)b...)
Affinity DataIC50: 1.85E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297096((S)-N-cyclopentyl-2-(methylthio)-N-(pyrrolidin-3-y...)
Affinity DataIC50: 1.87E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297103((S)-N-cyclobutyl-2-isopropyl-N-(pyrrolidin-3-yl)be...)
Affinity DataIC50: 1.90E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297090((S)-N-(cyclobutylmethyl)-2-methyl-N-(pyrrolidin-3-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297091((S)-N-(cyclobutylmethyl)-2-(methylthio)-N-(pyrroli...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297093((S)-2-chloro-N-(cyclobutylmethyl)-N-(pyrrolidin-3-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297082((S)-N-cyclobutyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297095((S)-2-(methylthio)-N-propyl-N-(pyrrolidin-3-yl)ben...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297097((S)-2-(methylthio)-N-phenyl-N-(pyrrolidin-3-yl)ben...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297099((S)-N-isopropyl-N-(pyrrolidin-3-yl)-2-(trifluorome...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297101((S)-N-(cyclopropylmethyl)-N-(pyrrolidin-3-yl)-2-(t...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297083((S)-N-phenyl-N-(pyrrolidin-3-yl)-2-(trifluoromethy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297105((S)-2-isopropyl-N-propyl-N-(pyrrolidin-3-yl)benzam...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of CYP3A4 using felodipine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 2.60E+4nMAssay Description:Blockade of Nav1.5 sodium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297082((S)-N-cyclobutyl-2-(methylthio)-N-(pyrrolidin-3-yl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
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