Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 3406
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33203(quinazolinone, 2)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The Institute of Cancer Research

LigandPNGBDBM33216(pyrazolopyridine, (R)-14)
Affinity DatapH: 7.5 T: 2°CAssay Description:CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The Institute of Cancer Research

LigandPNGBDBM33214(pyrazolopyridine, 13)
Affinity DatapH: 7.5 T: 2°CAssay Description:CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The Institute of Cancer Research

LigandPNGBDBM33213(pyrazolopyridine, 12)
Affinity DatapH: 7.5 T: 2°CAssay Description:CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The Institute of Cancer Research

LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DatapH: 7.5 T: 2°CAssay Description:CDK1 kinase activity was measured in a DELFIA based HTScan CDK1/CycB kinase assay kit (Cell Signalling Technology) that monitors biotinylated substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33209(2-methylsulfanyl imidazol-4-one, 8)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33208(thiazole, 7)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33206(thiazoloazepinyl acetamide, 5)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33203(quinazolinone, 2)
Affinity DatapH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33209(2-methylsulfanyl imidazol-4-one, 8)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33202(benzisoxazole, 1)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33204(N-phenylquinazolin-4-amine, 3)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33205(N-(3-methoxybenzyl)quinazolin-4-amine, 4)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33206(thiazoloazepinyl acetamide, 5)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33207(benzothienopyrimidinone, 6)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33208(thiazole, 7)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33210(4-(7H-purin-6-yl)morpholine | purine, 9)
Affinity DatapH: 7.5 T: 2°CAssay Description:AlphaScreen (PerkinElmer Life Sciences, Inc) was performed in opaque 384-well polypropylene plates. The assay relies on hydrogel coated Donor and Acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33214(pyrazolopyridine, 13)
Affinity DataIC50: 290nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33213(pyrazolopyridine, 12)
Affinity DataIC50: 390nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33216(pyrazolopyridine, (R)-14)
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33217(pyrazolopyridine, (S)-14)
Affinity DataIC50: 860nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33215(racemic | pyrazolopyridine, (Rac)-14)
Affinity DataIC50: 890nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

LigandPNGBDBM33214(pyrazolopyridine, 13)
Affinity DataIC50: 4.60E+3nMpH: 7.4 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

LigandPNGBDBM33216(pyrazolopyridine, (R)-14)
Affinity DataIC50: 5.90E+3nMpH: 7.4 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

LigandPNGBDBM33213(pyrazolopyridine, 12)
Affinity DataIC50: 7.40E+3nMpH: 7.4 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33211(purine, 10)
Affinity DataIC50: 9.20E+3nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33210(4-(7H-purin-6-yl)morpholine | purine, 9)
Affinity DataIC50: 4.20E+4nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
The Institute of Cancer Research

LigandPNGBDBM33207(benzothienopyrimidinone, 6)
Affinity DataIC50: 5.20E+4nMpH: 7.5 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk2(Human)
The Institute of Cancer Research

LigandPNGBDBM33212(pyrazolo pyridine, 11)
Affinity DataIC50: 7.40E+4nMpH: 7.4 T: 2°CAssay Description:CHK kinase function was measured in a DELFIA assay in order to monitor phosphorylation of a CDC25C peptide using a specific phospho antibody. The enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2009
Entry Details Article
PubMed