Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50030298
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(CHEMBL357076 | J-113397 | 1-((3R,4R)-1-Cyclooctylm...)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293857(1-(1,3-dihydroxypropan-2-yl)-3-(1-((1R,3S,4S)-spir...)
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293857(1-(1,3-dihydroxypropan-2-yl)-3-(1-((1R,3S,4S)-spir...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 2.70E+3nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 4.50E+3nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293857(1-(1,3-dihydroxypropan-2-yl)-3-(1-((1R,3S,4S)-spir...)
Affinity DataIC50: 6.20E+3nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 6.80E+3nMAssay Description:Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from human cloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from human cloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293857(1-(1,3-dihydroxypropan-2-yl)-3-(1-((1R,3S,4S)-spir...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naltrindole from human cloned delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293857(1-(1,3-dihydroxypropan-2-yl)-3-(1-((1R,3S,4S)-spir...)
Affinity DataIC50: 1.10E+4nMAssay Description:Displacement of [3H]U69593 from human cloned kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of dextrometorphan O-demethylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells coexpressing IKr channel proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as inhibition of testosterone 6-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of diclofenac 4'-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as inhibition of paclitaxel 6-alpha-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as inhibition of acetophenacetin odeethylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed