Compile Data Set for Download or QSAR
Report error Found 128 Enz. Inhib. hit(s) with all data for entry = 50030285
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277679(N-(4-(4-(4-tert-butylpiperazin-1-yl)-6-(5-methyl-1...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293671(N-(4-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)quinaz...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293699(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-phenylpy...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293669(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277640(N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyr...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293689(N-methyl-N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)qu...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277678(N-(4-(4-(4-cyclopropylpiperazin-1-yl)-6-(5-methyl-...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293686(N-(5-methyl-1H-pyrazol-3-yl)-2-(naphthalen-2-ylthi...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293690(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277679(N-(4-(4-(4-tert-butylpiperazin-1-yl)-6-(5-methyl-1...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277586(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperid...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277639(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(4-methy...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277637(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-morpholi...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293682(2-(3,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293687(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293693(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-phenylpy...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293698(N-(4-(4-(azetidin-1-yl)-6-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293700(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(pyridin...)
Affinity DataKi: <3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293679(2-(2,3-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277638(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperaz...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293695(N-(4-(4-cyclopropyl-6-(5-methyl-1H-pyrazol-3-ylami...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293697(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(pyridin...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293677(2-(3-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277585(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293676(2-(2-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293681(2-(2,6-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293694(N-(4-(4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)py...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293678(2-(4-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  6nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277586(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperid...)
Affinity DataKi:  8nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  8nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293684(2-(4-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  9nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293688(tert-butyl 4-(4-(5-methyl-1H-pyrazol-3-ylamino)qui...)
Affinity DataKi:  9nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277678(N-(4-(4-(4-cyclopropylpiperazin-1-yl)-6-(5-methyl-...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293696(N-(4-(4-tert-butyl-6-(5-methyl-1H-pyrazol-3-ylamin...)
Affinity DataKi:  10nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277679(N-(4-(4-(4-tert-butylpiperazin-1-yl)-6-(5-methyl-1...)
Affinity DataKi:  11nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277585(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-...)
Affinity DataKi:  11nMAssay Description:Inhibition of Aurora-CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277637(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-morpholi...)
Affinity DataKi:  14nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293671(N-(4-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)quinaz...)
Affinity DataKi:  15nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293682(2-(3,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi: >15nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293689(N-methyl-N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)qu...)
Affinity DataKi:  17nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293673(N2-methyl-N4-(5-methyl-1H-pyrazol-3-yl)-N2-phenylq...)
Affinity DataKi:  17nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293685(2-(3,4-dimethoxyphenylthio)-N-(5-methyl-1H-pyrazol...)
Affinity DataKi:  17nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  18nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277638(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperaz...)
Affinity DataKi:  18nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293692(N-(4-(4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)py...)
Affinity DataKi:  18nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277639(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(4-methy...)
Affinity DataKi:  20nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293675(N-(5-methyl-1H-pyrazol-3-yl)-2-(phenylthio)quinazo...)
Affinity DataKi:  20nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
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