Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50028720
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258453(3-(2-chloro-4-((5-isopropyl-3-((2,4,6-trichlorophe...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258281(3-(2-chloro-4-((3-((2-chloro-6-fluorophenoxy)methy...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258282(3-(2-chloro-4-((3-((2,6-difluorophenoxy)methyl)-5-...)
Affinity DataEC50:  720nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258283(3-(2-chloro-4-((3-((2,3-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  630nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258323(3-(2-chloro-4-((3-((2,4-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  690nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258421(3-(2-chloro-4-((3-((2,5-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258422(3-(2-chloro-4-((3-((3,4-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258423(3-(2-chloro-4-((3-((3,5-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258451(3-(2-chloro-4-((3-((2,6-dichloro-4-fluorophenoxy)m...)
Affinity DataEC50:  540nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258452(3-(2-chloro-4-((5-isopropyl-3-((2,4,6-trifluorophe...)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258852(3-(2-chloro-4-((3-((2,6-dimethylphenoxy)methyl)-5-...)
Affinity DataEC50:  56nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258484(3-(2-chloro-4-((3-((4-chloro-2,6-dimethylphenoxy)m...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258485(3-(2-chloro-4-((5-isopropyl-3-((naphthalen-2-yloxy...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258486(3-(2-chloro-4-((5-isopropyl-3-((naphthalen-1-yloxy...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258511(3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-(1-methyl...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258512(3-(2-chloro-4-((3-((trans)-2-(2,6-dichlorophenyl)c...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258513(3-(2-chloro-4-((5-cyclobutyl-3-(2,6-dichlorophenyl...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258556(3-(2-chloro-4-((5-cyclopentyl-3-(2,6-dichloropheny...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258557(3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-(pentan-3...)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258558((S)-3-(4-((5-sec-butyl-3-(2,6-dichlorophenyl)isoxa...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258745(3-(2-chloro-4-((3-((2,6-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  89nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM30335(CHEMBL469135 | 3-aryl isoxazole analog, 6d)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258676(3-(4-((3-benzyl-5-isopropylisoxazol-4-yl)methoxy)-...)
Affinity DataEC50:  230nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258677(3-(2-chloro-4-((5-isopropyl-3-phenethylisoxazol-4-...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258710(3-(2-chloro-4-((5-isopropyl-3-(3-phenylpropyl)isox...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258711(3-(2-chloro-4-((3-(2,6-dichlorophenethyl)-5-isopro...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258712(3-(4-((3-(tert-butoxymethyl)-5-isopropylisoxazol-4...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258713(3-(2-chloro-4-((3-(hydroxymethyl)-5-isopropylisoxa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258744(3-(2-chloro-4-((5-isopropyl-3-(phenoxymethyl)isoxa...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258586((R)-3-(4-((5-sec-butyl-3-(2,6-dichlorophenyl)isoxa...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258746(3-(2-chloro-4-((3-((2,6-dichlorophenylamino)methyl...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258776(3-(2-chloro-4-((3-((3,5-dichloropyridin-4-ylamino)...)
Affinity DataEC50:  420nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258777(3-(2-chloro-4-((3-((2,6-dichlorophenylthio)methyl)...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258778(3-(2-chloro-4-((3-((2,6-dichlorophenylsulfinyl)met...)
Affinity DataEC50:  72nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258808(3-(2-chloro-4-((3-((2,6-dichlorophenylsulfonyl)met...)
Affinity DataEC50:  390nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258809(3-(2-chloro-4-((3-((2-chlorophenoxy)methyl)-5-isop...)
Affinity DataEC50:  82nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258810(3-(2-chloro-4-((3-((3-chlorophenoxy)methyl)-5-isop...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human FXR assessed as SRC1 coactivator peptide recruitment by cell free FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258850(3-(2-chloro-4-((3-((4-chlorophenoxy)methyl)-5-isop...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258851(3-(2-chloro-4-((3-((2-chloro-6-methylphenoxy)methy...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258453(3-(2-chloro-4-((5-isopropyl-3-((2,4,6-trichlorophe...)
Affinity DataEC50:  58nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258281(3-(2-chloro-4-((3-((2-chloro-6-fluorophenoxy)methy...)
Affinity DataEC50:  74nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258282(3-(2-chloro-4-((3-((2,6-difluorophenoxy)methyl)-5-...)
Affinity DataEC50:  2.20E+3nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258283(3-(2-chloro-4-((3-((2,3-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  480nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258323(3-(2-chloro-4-((3-((2,4-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  620nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258421(3-(2-chloro-4-((3-((2,5-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258422(3-(2-chloro-4-((3-((3,4-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258423(3-(2-chloro-4-((3-((3,5-dichlorophenoxy)methyl)-5-...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258451(3-(2-chloro-4-((3-((2,6-dichloro-4-fluorophenoxy)m...)
Affinity DataEC50:  87nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50258452(3-(2-chloro-4-((5-isopropyl-3-((2,4,6-trifluorophe...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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