Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50039085
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310430(N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide | C...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310434(N-(1-benzofuran-3-ylmethyl)sulfamide | CHEMBL10771...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310436(N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide | ...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310429(N-(1-naphthylmethyl)sulfamide | CHEMBL1088203)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50003655(Phenytoin)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of carbonic anhydrase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310433(N-[(2-methyl-1-benzofuran-3-yl)methyl]sulfamide | ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310431(N-[(5-fluoro-1-benzothien-3-yl)methyl]sulfamide | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50031299(CHEMBL741 | BW-430C | 6-(2,3-Dichloro-phenyl)-[1,2...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310438(N-[(5-methyl-1-benzothien-3-yl)methyl]sulfamide | ...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310432(N-[(1-methyl-1H-indol-3-yl)methyl]sulfamide | CHEM...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl...)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310435(N-[(5-bromo-1-benzothien-3-yl)methyl]sulfamide | C...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310428(rac-N-[1-(1-benzothien-3-yl)ethyl]sulfamide | CHEM...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-ben...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of rat Cav2.2 channel expressed in 0.07 Hz frequency-stimulated HEK cells by whole-cell patch-clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310437(N-(1H-indol-3-ylmethyl)sulfamide | CHEMBL1084673)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl...)
Affinity DataKi:  300nMAssay Description:Inhibition of human carbonic anhydrase 2 by ThermoFluor methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed