Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50028610
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277775((3R,4R)-3-(4-(3,5-dimethylphenoxy)phenyl)-1-oxo-2-...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277776((3R,4R)-3-(4-(3,4-dimethylphenoxy)phenyl)-1-oxo-2-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277814((3R,4R)-2-(cyclopropylmethyl)-1-oxo-3-(4-phenoxyph...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277728((3R,4R)-3-(4-((cis)-4-methylcyclohexyloxy)phenyl)-...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277853((3R,4R)-3-(3,4-dichlorophenyl)-2-(2-ethylbutyl)-1-...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277887((3R,4R)-3-(benzo[d]thiazol-2-yl)-2-(2-ethylbutyl)-...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277729((3R,4R)-2-ethyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277852((3R,4R)-3-(3,4-dichlorophenyl)-2-((S)-2-methylbuty...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277888((3R,4R)-3-(benzofuran-2-yl)-2-((S)-2-methylbutyl)-...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277777((3R,4R)-1-oxo-2-propyl-3-(4-(5-(trifluoromethyl)py...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277849((3R,4R)-3-(3,4-dichlorophenyl)-1-oxo-2-propyl-1,2,...)
Affinity DataIC50: 89nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277774((3R,4R)-3-(4-(benzyloxy)phenyl)-1-oxo-2-propyl-1,2...)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277851((3R,4R)-3-(benzofuran-2-yl)-1-oxo-2-propyl-1,2,3,4...)
Affinity DataIC50: 119nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277813((3R,4R)-2-methyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4...)
Affinity DataIC50: 156nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277850((3R,4R)-3-(3-chlorophenyl)-1-oxo-2-propyl-1,2,3,4-...)
Affinity DataIC50: 228nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277730((3R,4R)-3-(4-methoxyphenyl)-1-oxo-2-propyl-1,2,3,4...)
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed