Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 3221
LigandPNGBDBM29532((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,...)
Affinity DataEC50:  1.00E+4nMAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29528(ML10302 scaffold, 9{a;y})
Affinity DataAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29529(ML10302 scaffold, 14)
Affinity DataEC50:  9.00E+3nMAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29531(ML10302 scaffold, 9{b;w})
Affinity DataKi:  2nM ΔG°:  -49.7kJ/mole EC50:  68nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29526(CHEMBL286136 | 2-Piperidinoethyl 4-amino-5-chloro-...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/mole EC50:  51nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29527(ML10302 scaffold, 9{a;q})
Affinity DataKi:  5nM ΔG°:  -47.4kJ/mole EC50:  18nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29530(ML10302 scaffold, 19)
Affinity DataKi:  12nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29529(ML10302 scaffold, 14)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/mole EC50:  9nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29528(ML10302 scaffold, 9{a;y})
Affinity DataKi:  111nM ΔG°:  -39.7kJ/mole EC50:  4nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  1.05E+3nM ΔG°:  -34.1kJ/mole EC50:  12nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed