Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50028548
TargetMitogen-activated protein kinase 10(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 16nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 17nMAssay Description:Inhibition of to JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 590nMAssay Description:Inhibition of CDK2/cyclinAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 860nMAssay Description:Inhibition of MKK7betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 920nMAssay Description:Inhibition of MKK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SPAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of SAPK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of MAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of IKKbMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of SAPK2bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SAPK2aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of P70s6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AMPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277947(N-(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-py...)
Affinity DataKi:  9nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277909(N-cyclopentyl-4-(3-(tetrahydro-2H-pyran-3-yl)-1H-p...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277869(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclopent...)
Affinity DataKi:  26nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277838(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclohexy...)
Affinity DataKi:  27nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277948(N-(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-py...)
Affinity DataKi:  28nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277946(3-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  36nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277873(N-isopropyl-4-(3-(tetrahydro-2H-pyran-3-yl)-1H-pyr...)
Affinity DataKi:  43nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277836(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-isopropyl...)
Affinity DataKi:  48nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277907(N-isopropyl-4-(3-(1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataKi:  101nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277837(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cycloprop...)
Affinity DataKi:  151nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277908(N-(1-methylpiperidin-4-yl)-4-(3-(6-methylpyridin-3...)
Affinity DataKi:  162nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277905(N-isopropyl-4-(3-(tetrahydro-2H-pyran-4-yl)-1H-pyr...)
Affinity DataKi:  169nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277868((R)-3-(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)pyrim...)
Affinity DataKi:  315nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277872(N-isopropyl-4-(3-(tetrahydro-2H-pyran-2-yl)-1H-pyr...)
Affinity DataKi:  381nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277906(N-isopropyl-4-(3-(piperidin-3-yl)-1H-pyrazol-4-yl)...)
Affinity DataKi:  530nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.02E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.57E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277835(4-methylpyrimidine-2-thiol | CHEMBL455772)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277871(N-isopropyl-4-(1H-pyrazol-4-yl)pyrimidin-2-amine |...)
Affinity DataKi:  2.73E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed