Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 3235
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29709(Pyridoimidazolone, 5i)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29705(Pyridoimidazolone, 5e)
Affinity DataIC50: 14nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29708(Pyridoimidazolone, 5h)
Affinity DataIC50: 21nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29715(Pyridoimidazolone, 5o)
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29701(Pyridoimidazolone, 5a)
Affinity DataIC50: 23nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29710(Pyridoimidazolone, 5j)
Affinity DataIC50: 27nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29723(Pyridoimidazolone, 5w)
Affinity DataIC50: 28nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29722(Pyridoimidazolone, 5v)
Affinity DataIC50: 29nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29724(Pyridoimidazolone, 5x)
Affinity DataIC50: 40nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 43nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29717(Pyridoimidazolone, 5q)
Affinity DataIC50: 45nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29719(Pyridoimidazolone, 5s)
Affinity DataIC50: 46nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29711(Pyridoimidazolone, 5k)
Affinity DataIC50: 52nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29718(Pyridoimidazolone, 5r)
Affinity DataIC50: 60nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29720(Pyridoimidazolone, 5t)
Affinity DataIC50: 61nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29725(Pyridoimidazolone, 26)
Affinity DataIC50: 85nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29704(Pyridoimidazolone, 5d)
Affinity DataIC50: 100nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29716(Pyridoimidazolone, 5p)
Affinity DataIC50: 163nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29721(Pyridoimidazolone, 5u)
Affinity DataIC50: 305nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29713(Pyridoimidazolone, 5m)
Affinity DataIC50: 600nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29738(Pyridoimidazolone, 29b)
Affinity DataIC50: 850nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29714(Pyridoimidazolone, 5n)
Affinity DataIC50: 860nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29712(Pyridoimidazolone, 5l)
Affinity DataIC50: 2.84E+3nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29733(Pyridoimidazolone, 28b)
Affinity DataIC50: 1.00E+4nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29735(Pyridoimidazolone, 28d)
Affinity DataIC50: 1.00E+4nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29736(Pyridoimidazolone, 28e)
Affinity DataIC50: 1.00E+4nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29742(Pyridoimidazolone, 29f)
Affinity DataIC50: 1.22E+4nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29729(Pyridoimidazolone, 27d)
Affinity DataIC50: 1.40E+4nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29727(Pyridoimidazolone, 27b)
Affinity DataIC50: 1.59E+4nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29732(Pyridoimidazolone, 28a)
Affinity DataIC50: 1.67E+4nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29728(Pyridoimidazolone, 27c)
Affinity DataIC50: 1.72E+4nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29743(Pyridoimidazolone, 29g)
Affinity DataIC50: 3.25E+4nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29740(Pyridoimidazolone, 29d)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29739(Pyridoimidazolone, 29c)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29741(Pyridoimidazolone, 29e)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29737(Pyridoimidazolone, 29a)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29726(Pyridoimidazolone, 27a)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29734(Pyridoimidazolone, 28c)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29731(Pyridoimidazolone, 27f)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29730(Pyridoimidazolone, 27e)
Affinity DataIC50: 1.00E+5nMAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29707(Pyridoimidazolone, 5g)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29702(Pyridoimidazolone, 5b)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29703(Pyridoimidazolone, 5c)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandPNGBDBM29706(Pyridoimidazolone, 5f)
Affinity DataIC50: 1.00E+5nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed