Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50028468
TargetMetabotropic glutamate receptor 1(Human)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278288BDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278288BDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278286BDBM50278286(N4-(2,3-dihydro-1H-inden-2-yl)-N6-(2-methoxyethyl)...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278407BDBM50278407(N-cycloheptyl-6-(2-morpholinoethoxy)pyrido[3,4-d]p...)
Affinity DataKi:  6nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278361BDBM50278361(N4-cyclohexyl-N6-(2-morpholinoethyl)pyrido[3,4-d]p...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278289BDBM50278289(N4-cyclohexyl-N6-(2-methoxyethyl)pyrido[3,4-d]pyri...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278112BDBM50278112(N4-(2,3-dihydro-1H-inden-2-yl)-N6-methylpyrido[3,4...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278358BDBM50278358(1-(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-...)
Affinity DataKi:  20nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278232BDBM50278232(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Affinity DataKi:  21nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278114BDBM50278114(N-cyclohexylquinazolin-4-amine | CHEMBL513012)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278231BDBM50278231(N4,N6-bis(2,3-dihydro-1H-inden-2-yl)pyrido[3,4-d]p...)
Affinity DataKi:  31nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278357BDBM50278357(3-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Affinity DataKi:  33nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278153BDBM50278153(N-(2,3-dihydro-1H-inden-2-yl)quinazolin-4-amine | ...)
Affinity DataKi:  34nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278362BDBM50278362(N-cyclohexyl-6-(2-morpholinoethoxy)pyrido[3,4-d]py...)
Affinity DataKi:  42nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278111BDBM50278111(N4-(2,3-dihydro-1H-inden-2-yl)-N4,N6-dimethylpyrid...)
Affinity DataKi:  54nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278291BDBM50278291(N-cyclohexyl-6-(2-methoxyethoxy)pyrido[3,4-d]pyrim...)
Affinity DataKi:  101nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278287BDBM50278287(N4-(2,3-dihydro-1H-inden-2-yl)-N6-(2-(dimethylamin...)
Affinity DataKi:  102nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278113BDBM50278113(N-(2,3-dihydro-1H-inden-2-yl)-6-methoxypyrido[3,4-...)
Affinity DataKi:  115nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278229BDBM50278229(2-(6-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278228BDBM50278228(N6-(2,3-dihydro-1H-inden-2-yl)-N4-methylpyrido[3,4...)
Affinity DataKi:  160nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278290BDBM50278290(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Affinity DataKi:  177nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278853BDBM50278853(N4-(2,3-dihydro-1H-inden-2-yl)-N6,N6-dimethylpyrid...)
Affinity DataKi:  185nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278850BDBM50278850(N4-cyclohexyl-N6,N6-dimethylpyrido[3,4-d]pyrimidin...)
Affinity DataKi:  199nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278360BDBM50278360(N6-(3-aminopropyl)-N4-cyclohexylpyrido[3,4-d]pyrim...)
Affinity DataKi:  200nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278849BDBM50278849(N4-(3-chloro-4-fluorophenyl)pyrido[3,4-d]pyrimidin...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278110BDBM50278110(N4-(2,3-dihydro-1H-inden-2-yl)-N4,N6,N6-trimethylp...)
Affinity DataKi:  300nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278116BDBM50278116(4-(cyclohexyloxy)quinazoline | CHEMBL471866)
Affinity DataKi:  694nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278852BDBM50278852(N6,N6-dimethyl-N4-(pentan-2-yl)pyrido[3,4-d]pyrimi...)
Affinity DataKi:  858nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278851BDBM50278851((S)-N6,N6-dimethyl-N4-(1-phenylethyl)pyrido[3,4-d]...)
Affinity DataKi:  1.40E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278227BDBM50278227(N-(2,3-dihydro-1H-inden-2-yl)isoquinolin-1-amine |...)
Affinity DataKi:  1.65E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278359BDBM50278359(N6-(2-aminoethyl)-N4-cyclohexylpyrido[3,4-d]pyrimi...)
Affinity DataKi:  2.20E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278288BDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278230BDBM50278230(2,2'-(pyrido[3,4-d]pyrimidine-4,6-diylbis(azanediy...)
Affinity DataKi:  6.15E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Medical Research Council Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50278115BDBM50278115(N-cyclohexylquinolin-4-amine | CHEMBL449616)
Affinity DataKi:  6.16E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed