Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50028109
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human adenosine A2A receptor assessed as inhibition of CGS-21680-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM26237(CHEMBL458242 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human adenosine A2A receptor assessed as inhibition of CGS-21680-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266381(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-oxopyrrolidin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human adenosine A2A receptor assessed as inhibition of CGS-21680-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266505(N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2-hydroxyph...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM26237(CHEMBL458242 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266476(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-(5-met...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266384(N-[6-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(3,5-dime...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255246(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxyme...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266474(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((S)-4-methoxy-(...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266415(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-methoxymethyl...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266476(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-(5-met...)
Affinity DataKi:  10.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266381(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-oxopyrrolidin...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266504(N-[6-((S)-2-Methoxymethylpyrrolidin-1-yl)-2-thiazo...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataKi:  19nMAssay Description:Inhibition of human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255188([2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxymeth...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255185(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-thiazo...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266475(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-4-methoxy-(...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266441(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-hydroxyme...)
Affinity DataKi:  25.8nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266412(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-propylpyrroli...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266503(N-[6-((S)-2-Methoxymethylpyrrolidin-1-yl)-2-thioph...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266385(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-methylpyrroli...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266472(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-[(R)-2-(pyridin-...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255247(1-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxyme...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255187(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-pyridi...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266502(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-thioph...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266443(N-[2-(3,5-Dimethylpyrazol--yl)-6-((R)-2-methoxymet...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]ZM241385 from rat adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255248(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxyme...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255186(N-[6-((S)-2-Methoxymethylpyrrolidin-1-yl)-2-pyridi...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255246(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxyme...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266472(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-[(R)-2-(pyridin-...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255187(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-pyridi...)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266380(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-piperidin-1-ylpy...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255248(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxyme...)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255249(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-diethylamino-1-y...)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255250(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-pyrrolidin-1-ylp...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255184(N-[6-((S)-2-Methoxymethylpyrrolidin-1-yl)-2-(5-met...)
Affinity DataKi:  119nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255186(N-[6-((S)-2-Methoxymethylpyrrolidin-1-yl)-2-pyridi...)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataKi:  145nMAssay Description:Inhibition of human adenosine A2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255185(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-thiazo...)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxyme...)
Affinity DataKi:  162nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266502(N-[6-((R)-2-Methoxymethylpyrrolidin-1-yl)-2-thioph...)
Affinity DataKi:  203nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266413((R)-1-[6-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)p...)
Affinity DataKi:  205nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50255184(N-[6-((S)-2-Methoxymethylpyrrolidin-1-yl)-2-(5-met...)
Affinity DataKi:  215nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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